A Selective Culture Medium for Screening Ceftazidime-Avibactam Resistance in Enterobacterales and Pseudomonas aeruginosa

被引：11

作者：

Sadek, Mustafa ^{[1
]}

Poirel, Laurent ^{[1
,2
,3
]}

Tinguely, Camille ^{[1
]}

Nordmann, Patrice ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Fribourg, Fac Sci & Med, Med & Mol Microbiol, Fribourg, Switzerland

[2] Univ Fribourg, INSERM European Unit IAME, Fribourg, Switzerland

[3] Univ Fribourg, Swiss Natl Reference Ctr Emerging Antibiot Resist, Fribourg, Switzerland

[4] Univ Lausanne, Inst Microbiol, Lausanne, Switzerland

[5] Univ Hosp Ctr, Lausanne, Switzerland

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2020年 / 58卷 / 09期

基金：

瑞士国家科学基金会;

关键词：

ceftazidime; avibactam; screening; Enterobacterales; Pseudomonas aeruginosa; INFECTIONS;

D O I：

10.1128/JCM.00965-20

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The SuperCAZ/AVI medium was developed for screening ceftazidime-avibactam (CZA) resistance among Gram-negative bacteria (Enterobacterales and Pseudomonas aeruginosa). It was evaluated using 50 CZA-susceptible and 42 CZA-resistant Gram-negative isolates. Its sensitivity and specificity of detection were 100%. Excellent performance of the medium was also observed by testing spiked stools, with the lower limit of detection ranging from 10(1) to 10(2) CFU/ml. This screening medium provides the opportunity to detect CZA-resistant isolates regardless of their resistance mechanisms.

引用

页数：5

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