Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases

被引:6
|
作者
Wang, Lu [1 ,2 ]
Xu, Haojie [1 ,2 ]
Yang, Huaxia [1 ,2 ,3 ]
Zhou, Jiaxin [1 ,2 ,3 ]
Zhao, Lidan [1 ,2 ,3 ]
Zhang, Fengchun [1 ,2 ,3 ]
机构
[1] Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Natl Clin Res Ctr Dermatol & Immunol Dis NCRC DID,, Beijing, Peoples R China
[2] Minist Educ, Key Lab Rheumatol & Clin Rheumatol, Beijing, Peoples R China
[3] Peking Union Med Coll Hosp, State Key Lab Complex Severe & Rare Dis, Beijing, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
基金
中国国家自然科学基金;
关键词
autoimmune diseases; glucose metabolism; glycosylation; gut microbiota; systemic lupus erythematosus; SYSTEMIC-LUPUS-ERYTHEMATOSUS; UROPATHOGENIC ESCHERICHIA-COLI; RHEUMATOID-ARTHRITIS; STERILE INFLAMMATION; INSULIN-RESISTANCE; EFFECTOR FUNCTION; IMMUNE-RESPONSES; T-CELLS; FUCOSYLATION; ANTIBODIES;
D O I
10.3389/fimmu.2022.952398
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Carbohydrates serve as important energy sources and structural substances for human body as well as for gut microbes. As evidenced by the advances in immunometabolism, glucose metabolism and adenosine triphosphate (ATP) generation are deeply involved in immune cell activation, proliferation, and signaling transduction as well as trafficking and effector functions, thus contributing to immune response programming and assisting in host adaption to microenvironment changes. Increased glucose uptake, aberrant expression of glucose transporter 1 (e.g., GLU1), and abnormal glycosylation patterns have been identified in autoimmunity and are suggested as partially responsible for the dysregulated immune response and the modification of gut microbiome composition in the autoimmune pathogenesis. The interaction between gut microbiota and host carbohydrate metabolism is complex and bidirectional. Their impact on host immune homeostasis and the development of autoimmune diseases remains to be elucidated. This review summarized the current knowledge on the crosstalk of glucose metabolism and glycosylation in the host with intestinal microbiota and discussed their possible role in the development and progression of autoimmune diseases. Potential therapeutic strategies targeting glucose metabolism and glycosylation in modulating gut ecosystem and treating autoimmune diseases were discussed as well.
引用
收藏
页数:16
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