Association of Nox1 and Vinculin With Colon Cancer Progression

被引：10
|
作者：
Sun, Zheng [1 ]
Liu, Feng [2 ]
机构：
[1] Guangzhou Med Univ, Affiliated Guangzhou Municipal Peoples Hosp 1, Dept Gastrointestinal Surg, Guangzhou 510180, Guangdong, Peoples R China
[2] Univ Calif Irvine, Sch Med, Dept Med, Chao Family Comprehens Canc Ctr, Irvine, CA 92697 USA
来源：
CANCER INVESTIGATION | 2013年 / 31卷 / 04期
关键词：
Nox1; Vinculin; Adhesion; Colon cancer progression; NADPH OXIDASE; E-CADHERIN; EXPRESSION; SUPEROXIDE; ROLES;
D O I：
10.3109/07357907.2013.789897
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Nox1 mRNA, protein, and activities were compared in the paired primary and metastatic colon adenocarcinoma cell lines SW480 and SW620, and in normal colon tissues and colon cancer tissues. Our results demonstrated that Nox1 levels were higher in the primary SW480 cells than that in metastatic SW620 cells and were not associated with colon cancer progression. We further discovered that vinculin protein level in SW620 was much higher than that in SW480 cells, whereas E-cadherin was lower. We conclude that vinculin and E-cadherin, but not Nox1, may serve as biomarkers for colon cancer progression.
引用
收藏
页码：273 / 278
页数：6
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