Association of Nox1 and Vinculin With Colon Cancer Progression

被引：10

作者：

Sun, Zheng ^{[1
]}

Liu, Feng ^{[2
]}

机构：

[1] Guangzhou Med Univ, Affiliated Guangzhou Municipal Peoples Hosp 1, Dept Gastrointestinal Surg, Guangzhou 510180, Guangdong, Peoples R China

[2] Univ Calif Irvine, Sch Med, Dept Med, Chao Family Comprehens Canc Ctr, Irvine, CA 92697 USA

来源：

CANCER INVESTIGATION | 2013年 / 31卷 / 04期

关键词：

Nox1; Vinculin; Adhesion; Colon cancer progression; NADPH OXIDASE; E-CADHERIN; EXPRESSION; SUPEROXIDE; ROLES;

D O I：

10.3109/07357907.2013.789897

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nox1 mRNA, protein, and activities were compared in the paired primary and metastatic colon adenocarcinoma cell lines SW480 and SW620, and in normal colon tissues and colon cancer tissues. Our results demonstrated that Nox1 levels were higher in the primary SW480 cells than that in metastatic SW620 cells and were not associated with colon cancer progression. We further discovered that vinculin protein level in SW620 was much higher than that in SW480 cells, whereas E-cadherin was lower. We conclude that vinculin and E-cadherin, but not Nox1, may serve as biomarkers for colon cancer progression.

引用

页码：273 / 278

页数：6

共 50 条

[1] Nox1 modulates colon epithelial cell homeostasis
Swanson, Phillip Alan, II
Neish, Andrew S.
FASEB JOURNAL, 2011, 25
[2] Roles of Nox1 and other Nox isoforms in cancer development
Kamata, Tohru
CANCER SCIENCE, 2009, 100 (08) : 1382 - 1388
[3] Effect of stable knockdown of NOX1 gene expression with siRNA in human colon cancer cells
Juhasz, Agnes
Antony, Smitha
Wu, Yongzhong
Lu, Jiamo
Jiang, Guojian
Liu, Han
Roy, Krishnendu
Doroshow, James H.
CANCER RESEARCH, 2012, 72
[4] Effect of Stable Knockdown of Nox1 Gene Expression with siRNA in Human Colon Cancer Cells
Juhasz, Agnes
Antony, Smitha
Wu, Yongzhong
Lu, Jiamo
Jiang, Guojian
Liu, Han
Roy, Krishnendu
Doroshow, James
FREE RADICAL BIOLOGY AND MEDICINE, 2013, 65 : S17 - S18
[5] Expression of NOX1, a superoxide-generating NADPH oxidase, in colon cancer and inflammatory bowel disease
Szanto, I
Rubbia-Brandt, L
Kiss, P
Steger, K
Banfi, B
Kovari, E
Herrmann, F
Hadengue, A
Krause, KH
JOURNAL OF PATHOLOGY, 2005, 207 (02): : 164 - 176
[6] Nox1 promotes colon cancer cell metastasis via activation of the ADAM17 pathway
Wang, H. -P.
Wang, X.
Gong, L. -F.
Chen, W. -J.
Hao, Z.
Feng, S. -W.
Wu, Y. -B.
Ye, T.
Cai, Y. -K.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2016, 20 (21) : 4474 - 4481
[7] Disrupted regulation of Nox1 by protein disulfide isomerase-A1 in colon cancer cells with KRas overactivity
De Bessa, Tiphany
Pagano, Alessandra
Moretti, Ana Iochabel
Oliveira, Percillia
Kovacic, Herve
Laurindo, Francisco
FREE RADICAL BIOLOGY AND MEDICINE, 2018, 128 : S65 - S66
[8] DUAL NOX4/NOX1 INHIBITION BY SETANAXIB HALTS CHOLANGIOCARCINOMA PROGRESSION BY IMPAIRING CANCER ASSOCIATED FIBROBLAST ACTIVATION
Amengual, Josep
Gonzalez-Sanchez, Ester
Fuste, Noel P.
Pons, Gabriel
Sererols-Vinas, Laura
Alay, Ania
Hijazo-Pechero, Sara
Martin-Mur, Beatriz
Esteve-Codina, Anna
Ferrer, Joana
Gores, Gregory J.
Ilyas, Sumera I.
Calvisi, Diego
Aoudjehane, Lynda
Fouassier, Laura
Coulouarn, Cedric
Affo, Silvia
Fabregat, Isabel
Vaquero, Javier
FREE RADICAL BIOLOGY AND MEDICINE, 2024, 218 : 45 - 45
[9] Phosphorylation of Nox1 Regulates Association With NoxA1 Activation Domain
Streeter, Jennifer
Schickling, Brandon M.
Jiang, Shuxia
Stanic, Bojana
Thiel, William H.
Gakhar, Lokesh
Houtman, Jon C. D.
Miller, Francis J., Jr.
CIRCULATION RESEARCH, 2014, 115 (11) : 912 - +
[10] Identification and Characterization of a Novel NADPH Oxidase 1 (Nox1) Inhibitor That Suppresses Proliferation of Colon and Stomach Cancer Cells
Yamamoto, Tsuyoshi
Nakano, Hirofumi
Shiomi, Kazuro
Wanibuchi, Kiyofumi
Masui, Hisashi
Takahashi, Takashi
Urano, Yasuteru
Kamata, Tohru
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2018, 41 (03) : 419 - 426

← 1 2 3 4 5 →