Improve MEK/ERK targeting in mutant KRAS lung cancer

被引:0
|
作者
Chen, Zhao [1 ]
Weisberg, Ellen [1 ]
Cheng, Katherine [1 ]
Kung, Andrew L. [2 ]
Bradner, James [1 ]
Griffin, James [1 ]
Wong, Kwok-Kin [1 ]
机构
[1] Dana Farber Canc Inst, Boston, MA 02115 USA
[2] Columbia Univ, New York, NY USA
关键词
D O I
10.1158/1557-3125.RASONC14-B01
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
B01
引用
收藏
页数:1
相关论文
共 50 条
  • [21] RAF Suppression Synergizes with MEK Inhibition in KRAS Mutant Cancer Cells
    Lamba, Simona
    Russo, Mariangela
    Sun, Chong
    Lazzari, Luca
    Cancelliere, Carlotta
    Grernrum, Wipawadee
    Lieftink, Cor
    Bernards, Rene
    Di Nicolantonio, Federica
    Bardelli, Alberto
    CELL REPORTS, 2014, 8 (05): : 1475 - 1483
  • [22] Therapeutic benefit of targeting ERK in mutant KRAS in pancreatic ductal adenocarcinoma (PDAC)
    Hayes, Tikvah K.
    Neel, Nicole F.
    Chenard, Melissa
    Yeh, Jen Jen
    Samatar, Ahmed
    Der, Channing J.
    CANCER RESEARCH, 2013, 73
  • [23] Metabolic rewiring in mutant Kras lung cancer
    Kerr, Emma M.
    Martins, Carla P.
    FEBS JOURNAL, 2018, 285 (01) : 28 - 41
  • [24] STAT3 inhibitor sensitized KRAS-mutant lung cancers to RAF innioitor by activating MEK/ERK signaling pathway
    Wang, Zhenlin
    Yin, Mengchen
    Chu, Peilin
    Lou, Meiqing
    AGING-US, 2019, 11 (17): : 7187 - 7196
  • [25] Targeting the RAF-MEK-ERK pathway in cancer therapy
    Montagut, Clara
    Settleman, Jeff
    CANCER LETTERS, 2009, 283 (02) : 125 - 134
  • [26] Combined inhibition of MDM2 and MEK for KRAS mutant non-small cell lung cancer
    Hata, Aaron N.
    Archibald, Hannah L.
    Gomez-Caraballo, Maria D.
    DeBussche, Laurent R.
    Sidhu, Sukhvinder
    Watters, James
    Engelman, Jeffrey A.
    CANCER RESEARCH, 2014, 74 (19)
  • [27] Pulsatile MEK inhibition improves antitumor immunity and T-cell function in Kras mutant lung cancer
    Choi, Hyejin
    Deng, Jiehui
    Li, Shuai
    Silk, Tarik
    Brea, Elliott J.
    Boiarsky, Jonathan
    Akbay, Esra A.
    Smith, Paul D.
    Merghoub, Taha D.
    Wong, Kwok-Kin
    Wolchok, Jedd D.
    CANCER IMMUNOLOGY RESEARCH, 2019, 7 (02)
  • [28] Exploiting the heterogeneity of mutant Kras lung tumors to improve therapy
    Martins, Carla
    MOLECULAR CANCER THERAPEUTICS, 2017, 16 (10)
  • [29] Implication of targeting YAP1 in KRAS-mutant lung cancer cells.
    Shimomura, Iwao
    Yamamoto, Yusuke
    Tada, Yuji
    Tatsumi, Koichiro
    Ochiya, Takahiro
    MOLECULAR CANCER RESEARCH, 2020, 18 (08) : 39 - 40