Ratiometric Detection of Viscosity Using a Two-Photon Fluorescent Sensor

被引：117
|
作者：
Liu, Fei [1 ]
Wu, Tong [1 ]
Cao, Jianfang [1 ]
Cui, Shuang [2 ]
Yang, Zhigang [1 ]
Qiang, Xinxin [1 ]
Sun, Shiguo [1 ]
Song, Fengling [1 ]
Fan, Jiangli [1 ]
Wang, Jingyun [2 ]
Peng, Xiaojun [1 ]
机构：
[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China
[2] Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116024, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 05期
基金：
美国国家科学基金会;
关键词：
cells; fluorescence; sensors; two-photon microscopy; viscosity; MOLECULAR ROTORS; CELLS;
D O I：
10.1002/chem.201202646
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In the thick of it: A carbazole-based cyanine derivative has been used as a ratiometric fluorescent sensor to detect mitochondrial viscosities over the range 1-950 cP within live cells and living tissues by using two-photon microscopy. Its success is based on the fast- and low-barrier rotation around its methine bond (see figure) and the huge increase of the fluorescence quantum yield (QY) from the loss of mobility in viscous media. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1548 / 1553
页数：6
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