Polymer-coated liposomes resistant to enzymatic hydrolysis

被引：2
|
作者：
Gotoh, T
Hozawa, M
机构：
[1] Akita Univ, Dept Mat Proc Engn & Appl Chem Enviornm, Akita 0108502, Japan
[2] Tohoku Univ, Inst Multidisciplinary Res Adv Mat, Aoba Ku, Sendai, Miyagi 9808577, Japan
来源：
BIOTECHNOLOGY LETTERS | 2004年 / 26卷 / 07期
关键词：
liposomes; phospholipases; phospholipid bilayer membranes; proteoliposomes; stability;
D O I：
10.1023/B:BILE.0000021966.01506.5a
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A polymerizable electrolyte, 2-aminoethyl 1,6-heptadien-4-yl phosphate (AEHDP), which has the same hydrophilic head group as naturally occurring phospholipids, was prepared. Five equivalents of AEHDP were added to a suspension of liposomes (closed bilayer vesicles made of phospholipids) and layered on the liposomes. After polymerization by UV irradiation, the resulting polymer-coated liposomes were resistant to hydrolysis of their constituent phospholipids by phospholipase A(2).
引用
收藏
页码：611 / 614
页数：4
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