BCL-2 Family of Proteins and Mammary Cellular Fate

被引:22
|
作者
Colitti, M. [1 ]
机构
[1] Univ Udine, Dept Agr & Environm Sci, Fac Vet Med, I-33100 Udine, Italy
关键词
APOPTOSIS-INDUCING FACTOR; MITOCHONDRIAL APOPTOSIS; ANTIOXIDANT PATHWAY; DIETARY RESTRICTION; GENE TRANSCRIPTS; OXIDATIVE STRESS; GLAND INVOLUTION; FACTOR AIF; DEATH; BAX;
D O I
10.1111/j.1439-0264.2012.01134.x
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
This review focuses on the pro-apoptotic and anti-apoptotic Bcl-2 family members involved in apoptosis, which is the predominant process controlling cell remodelling during post-lactational mammary gland involution. The members of the Bcl-2 protein family, whose expression levels are under the control of lactogenic hormones, internally control this mechanism also during lactation. They can physically interact with each other, sometimes in an antagonistic manner. Mammary glands undergo repeated cycles of structural development, functional differentiation and regression, therefore provide a unique model for investigating this family of proteins that regulate the fate of the secretory cells and consequently milk yield. The involvement of Bcl-2 family members is reviewed in mammary tissue during morphogenesis, at different stages of lactation cycle and in comparison with dairy and laboratory animals.
引用
收藏
页码:237 / 247
页数:11
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