Direct visualization of hyaluronic acid polymer chain by self-assembled one-dimensional array of gold nanoparticles

被引：64
|
作者：
Lee, H [1 ]
Choi, SH [1 ]
Park, TG [1 ]
机构：
[1] Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea
来源：
MACROMOLECULES | 2006年 / 39卷 / 01期
关键词：
D O I：
10.1021/ma051929c
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Fabrication of one-dimensional array of gold nanoparticles, in which their self-assembly structures were dictated by a naturally occurring biopolymer, hyaluronic acid (HA), was investigated. The carboxylic acid groups of HA were chemically activated by 1-ethyl-3-(3-dimethylaminopropyl)-carboiimide hydrochloride (EDC) and 1-hydroxybenzotriazole (HOBT) and conjugated with cystamine dihydrochloride at pH 6.8 for 12 h. Transmission electron microscopy (TEM) was used to show the morphology of the Ha/Au nanoparticle array. Results show that direct visualization of a HA chain structure could be possible by the aligned gold nanoparticles in aqueous solution.
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页码：23 / 25
页数：3
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