Inflammation, immunity, and vaccines for Helicobacter pylori infection

被引：27
|
作者：
Velin, Dominique [1 ]
Straubinger, Kathrin [2 ]
Gerhard, Markus [2 ,3 ]
机构：
[1] Univ Lausanne Hosp, Dept Med, Serv Gastroenterol & Hepatol, Lausanne, Switzerland
[2] ImevaX GmbH, Munich, Germany
[3] Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, Munich, Germany
来源：
HELICOBACTER | 2016年 / 21卷
关键词：
H; pylori; innate and adaptive immunity; vaccine development; T-CELL; GASTRIC-CANCER; RETINOIC ACID; C57BL/6; MICE; PROTECTION; RESPONSES; ASTHMA; COLONIZATION; MACROPHAGES; PHAGOCYTOSIS;
D O I：
10.1111/hel.12336
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The tight control of the innate and adaptive immune responses in the stomach mucosa during chronic Helicobacter pylori infection is of prime importance for the bacteria to persist and for the host to prevent inflammation-driven diseases. This review summarizes recent data on the roles of innate and adaptive immune responses during H.pylori/host interactions. In addition, the latest preclinical developments of H.pylori vaccines are discussed with a special focus on the clinical trial reported by Zeng etal., who provided evidence that oral vaccination significantly reduces the acquisition of natural H.pylori infection in children.
引用
收藏
页码：26 / 29
页数：4
相关论文
共 50 条
  • [31] Helicobacter Pylori and Inflammation
    Ruggiero, Paolo
    CURRENT PHARMACEUTICAL DESIGN, 2010, 16 (38) : 4225 - 4236
  • [32] Prophylactic immunization to Helicobacter pylori infection using spore vectored vaccines
    Katsande, Paidamoyo M.
    Nguyen, Van Duy
    Nguyen, Thi Lan Phuong
    Nguyen, Thi Kim Cuc
    Mills, Gabrielle
    Bailey, David M. D.
    Christie, Graham
    Hong, Huynh Anh
    Cutting, Simon M.
    HELICOBACTER, 2023, 28 (04)
  • [33] Role of mast cells as a trigger of inflammation in Helicobacter pylori infection
    Yamamoto, J
    Watanabe, S
    Hirose, M
    Osada, T
    Ra, C
    Sato, N
    JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1999, 50 (01): : 17 - 23
  • [34] Unusual forms of gastric inflammation and their relationship to Helicobacter pylori infection
    Dixon, MF
    HELICOBACTER PYLORI: BASIC MECHANISMS TO CLINICAL CURE 2000, 2000, : 221 - 228
  • [35] Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation
    Mahdavi, J
    Sondén, B
    Hurtig, M
    Olfat, FO
    Forsberg, L
    Roche, N
    Ångström, J
    Larsson, T
    Teneberg, S
    Karlsson, KA
    Altraia, S
    Wadström, T
    Kersulyte, D
    Berg, DE
    Dubois, A
    Petersson, C
    Magnusson, KE
    Norberg, T
    Lindh, F
    Lundskog, BB
    Arnqvist, A
    Hammarström, L
    Borén, T
    SCIENCE, 2002, 297 (5581) : 573 - 578
  • [36] Role of mast cell as a trigger of inflammation in Helicobacter pylori infection
    Yamamoto, J
    Hirose, M
    Watanabe, S
    Sato, N
    GASTROENTEROLOGY, 1999, 116 (04) : A848 - A848
  • [37] Association of host immunity with Helicobacter pylori infection in recurrent gastric cancer
    Sato, Mayu
    Miura, Kou
    Kageyama, Chihiro
    Sakae, Hiroyuki
    Obayashi, Yuka
    Kawahara, Yoshiro
    Matsushita, Osamu
    Yokota, Kenji
    Okada, Hiroyuki
    INFECTIOUS AGENTS AND CANCER, 2019, 14 (1)
  • [38] The Role of Interleukin-17 in the Helicobacter pylori Induced Infection and Immunity
    Kabir, Shahjahan
    HELICOBACTER, 2011, 16 (01) : 1 - 8
  • [39] Helicobacter pylori infection as a model for gastrointestinal immunity and chronic inflammatory diseases
    Ernst, PB
    Takaishi, H
    Crowe, SE
    DIGESTIVE DISEASES, 2001, 19 (02) : 104 - 111
  • [40] Synthetic Lipopeptide Enhances Protective Immunity Against Helicobacter pylori Infection
    Xue, Ruo-Yi
    Guo, Mu-fei
    Guo, Ling
    Liu, Chang
    Li, Sun
    Luo, Jiao
    Nie, Li
    Ji, Lu
    Ma, Cong-Jia
    Chen, Da-Qun
    Sun, Si
    Jin, Zhe
    Zou, Quan-Ming
    Li, Hai-Bo
    FRONTIERS IN IMMUNOLOGY, 2019, 10
12345