Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors

被引：47
|
作者：
Prior, Allan M. [1 ]
Kim, Yunjeong [2 ]
Weerasekara, Sahani [1 ]
Moroze, Meghan [1 ]
Alliston, Kevin R. [3 ]
Uy, Roxanne Adeline Z. [3 ]
Groutas, William C. [3 ]
Chang, Kyeong-Ok [2 ]
Hua, Duy H. [1 ]
机构：
[1] Kansas State Univ, Dept Chem, Manhattan, KS 66506 USA
[2] Kansas State Univ, Coll Vet Med, Dept Diagnost Med & Pathobiol, Manhattan, KS 66506 USA
[3] Wichita State Univ, Dept Chem, Wichita, KS 67260 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 23期
基金：
美国国家科学基金会;
关键词：
Viral 3C and 3C-like protease inhibitors; Norovirus; Human rhinovirus; Severe acute respiratory syndrome; coronavirus; Coronavirus; 229E;
D O I：
10.1016/j.bmcl.2013.09.070
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A class of tripeptidyl transition state inhibitors containing a P1 glutamine surrogate, a P2 leucine, and a P3 arylalanines, was found to potently inhibit Norwalk virus replication in enzyme and cell based assays. An array of warheads, including aldehyde, a-ketoamide, bisulfite adduct, and a-hydroxyphosphonate transition state mimic, was also investigated. Tripeptidyls 2 and 6 possess antiviral activities against noroviruses, human rhinovirus, severe acute respiratory syndrome coronavirus, and coronavirus 229E, suggesting a broad range of antiviral activities. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6317 / 6320
页数：4
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