Synthesis, antibacterial activity and QSAR studies of 1,2-disubstituted-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines

被引：61
|
作者：
Tiwari, RK
Singh, D
Singh, J
Chhillar, AK
Chandra, R
Verma, AK [1 ]
机构：
[1] Univ Delhi, Dr BR Ambedkar Ctr Biomed Res, Synthet Organ Chem Res Lab, Delhi 110007, India
[2] Inst Genom & Integrated Biol, Biochem Res Lab, Delhi 110007, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 41卷 / 01期
关键词：
1,2,3,4-tetrahydroisoquinolines; antibacterial activity; linear free energy relationship (LFER); QSAR;
D O I：
10.1016/j.ejmech.2005.10.010
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Some new substituted-tetrahydroisoquinoline derivatives were synthesized and evaluated for their in vitro antimicrobial activities against the standard Gram positive and Gram negative strains: Staphylococcus aureus (ATCC 25923), S. epidermidis (WHO-6), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 4a-c proved to be effective with MIC 3.5-20 (mu g ml(-1)). Quantitative structure activity relationship (QSAR) studies with multiple linear regression analysis were applied to find correlation between different calculated molecular descriptors of the synthesized compounds and biological activity. (c) 2005 Elsevier SAS. All rights reserved.
引用
收藏
页码：40 / 49
页数：10
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