Influence of Weight of Pregnant Women on First Trimester Biochemical Markers Values

被引：0
|
作者：
Navolan, Dan [1 ]
Ionescu, Cringu Antoniu [2 ]
Carabineanu, Adrian [3 ]
Birsasteanu, Florin [4 ]
Cretu, Octavian [3 ]
Szasz, Florin [5 ]
Vladareanu, Simona [2 ]
Ciohat, Ioana [1 ]
Gidea, Ramona [3 ]
Nemescu, Dragos [6 ]
Farcas, Simona [7 ]
Andreescu, Nicoleta [7 ]
Simu, Sebastian [1 ]
Stoian, Dana [8 ]
机构：
[1] Victor Babes Univ Med & Pharm, Dept Obstetr Gynecol & Neonatol, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
[2] Carol Davila Univ Med & Pharm, Dept Obstet Gynecol & Neonatol, Bucharest, Romania
[3] Victor Babes Univ Med & Pharm, Dept Surg, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
[4] Victor Babes Univ Med & Pharm, Dept Radiol, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
[5] Univ Med & Pharm Oradea, Dept Obstet Gynecol, Oradea, Romania
[6] Grigore T Popa Univ Med & Pharm, Dept Obstetr Gynecol & Neonatol, 16 Univ Str, Iasi 700115, Romania
[7] Victor Babes Univ Med & Pharm, Dept Genet, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
[8] Victor Babes Univ Med & Pharm, Dept Endocrinol, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
来源：
REVISTA DE CHIMIE | 2017年 / 68卷 / 12期
关键词：
PAPP-A; free beta hCG; first trimester biochemical markers; aneuploidies; weight; software correction; 2ND-TRIMESTER; 1ST-TRIMESTER;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Values of first trimester biochemical markers (PAPP-A and free b-hCG) concentration are included in aneuploidies risk evaluation algorithm. Since both markers are produced by the fetus and placenta their concentration depends on the volume in which they are dissolved, respectively the weight of the pregnant women. Our study aimed to analyze the influence of maternal weight on first trimester biochemical markers concentration and the ability of the risk calculation software to correct this influence. Pregnancy-associated protein A (PAPP-A) and free beta chorionic gonadotropin hormone (free beta hCG) first trimester sera concentration respectively weight were measured in 1629 pregnant women. First trimester PAPP-A and free beta hCG concentrations inverse correlate with weight of pregnant women rho=-0.33, p<0.0001, respectively rho=-0.18, p<0.0001. Weight of pregnant women inversely correlates with multiple of median (MoM) values of first trimester markers too: rho=-0.38, p<0.0001 (PAPP-A), respectively rho=-0.17, p<0.0001 (free-b-hCG). The software counterbalances the influence of weight on biochemical markers values. PAPP-A corrected MoM (MoMc) values don't inversely correlate with the weight (rho=-0.03, p=0.12), whereas free beta hCG MoMc values showed an extremely weak inverse correlation (rho=-0.08, p=0.0008). The software counterbalances the influence of weight on PAPP-A values, whereas an extremely weak but insignificant inverse correlation between weight and free-beta hCG values persists after correction.
引用
收藏
页码：2836 / 2838
页数：3
相关论文
共 50 条
  • [41] Assessment of biochemical markers of bone: Turnover in pregnant women.
    Black, AJ
    Topping, J
    Durham, B
    Farquharson, RG
    Fraser, WD
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 1996, 11 : T563 - T563
  • [42] First-trimester markers of aneuploidy in women positive for HIV
    Savvidou, M. D.
    Samuel, I.
    Syngelaki, A.
    Poulton, M.
    Nicolaides, K. H.
    [J]. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2011, 118 (07) : 844 - 848
  • [43] The impact of vitamin D deficiency on some biochemical parameters and clinical outcome in Palestinian pregnant women during the first trimester
    Mwafy, Saleh Nazmy
    El- Nabi, Safaa Ramadan Abed
    Laqqan, Mohammed Marwan
    Yassin, Maged Mohamed
    [J]. PLOS ONE, 2023, 18 (03):
  • [44] The Relationship between Biochemical and Hemoglobin Results and Quality Index Scores of the Mediterranean Diet of Pregnant Women in the First and the Third Trimester
    Bulunc, Nazife Hurer
    Yildiz, Emine
    [J]. PROGRESS IN NUTRITION, 2021, 23 (04):
  • [45] First trimester risk assessment for trisomy 21 in twin pregnancies combining nuchal translucency and first trimester biochemical markers
    Prats, Pilar
    Rodriguez, Ignacio
    Comas, Carmina
    Puerto, Bienvenido
    [J]. PRENATAL DIAGNOSIS, 2012, 32 (10) : 927 - 932
  • [46] FIRST TRIMESTER THYROID FUNCTION IN PREGNANT WOMEN RESIDING IN SAINT PETERSBURG (RUSSIA): REFERENCE VALUES AND RISK OF GESTATIONAL DIABETES
    Popova, Polina V.
    Shilova, Ekaterina S.
    Tkachuk, Alexandra S.
    Dronova, Alexandra V.
    Anopova, Anna D.
    Nikolaeva, Alla E.
    Grineva, Elena N.
    [J]. DIABETES MELLITUS, 2018, 21 (01): : 34 - 41
  • [47] Does Active Smoking Influence the Second Trimester Biochemical Markers Concentrations?
    Navolan, Dan
    Birsasteanu, Florin
    Carabineanu, Adrian
    Cretu, Octavian
    Badiu, Diana Liana
    Ionescu, Cringu Antoniu
    Mehedintu, Claudia
    Vladareanu, Simona
    Craina, Marius
    Boia, Marioara
    Ciohat, Ioana
    Craciunescu, Mihaela
    Simu, Sebastian
    Nemescu, Dragos
    [J]. REVISTA DE CHIMIE, 2017, 68 (10): : 2234 - 2236
  • [48] Predictors of Preeclampsia in the First Trimester in Normotensive and Chronic Hypertensive Pregnant Women
    Vazquez, Susana
    Pascual, Julio
    Duran-Jorda, Xavier
    Hernandez, Jose Luis
    Crespo, Marta
    Oliveras, Anna
    [J]. JOURNAL OF CLINICAL MEDICINE, 2023, 12 (02)
  • [49] Prevalence of obesity among Bangladeshi pregnant women at their first trimester of pregnancy
    Goon, Shatabdi
    [J]. CENTRAL ASIAN JOURNAL OF GLOBAL HEALTH, 2013, 2 (02):
  • [50] The prevalence of underweight and probable undernutrition in first-trimester pregnant women
    Abayomi, J. C.
    Watkinson, H.
    Topping, J.
    Hackett, A. F.
    [J]. PROCEEDINGS OF THE NUTRITION SOCIETY, 2007, 66 : 63A - 63A
12345