Influence of Weight of Pregnant Women on First Trimester Biochemical Markers Values

被引：0
|
作者：
Navolan, Dan [1 ]
Ionescu, Cringu Antoniu [2 ]
Carabineanu, Adrian [3 ]
Birsasteanu, Florin [4 ]
Cretu, Octavian [3 ]
Szasz, Florin [5 ]
Vladareanu, Simona [2 ]
Ciohat, Ioana [1 ]
Gidea, Ramona [3 ]
Nemescu, Dragos [6 ]
Farcas, Simona [7 ]
Andreescu, Nicoleta [7 ]
Simu, Sebastian [1 ]
Stoian, Dana [8 ]
机构：
[1] Victor Babes Univ Med & Pharm, Dept Obstetr Gynecol & Neonatol, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
[2] Carol Davila Univ Med & Pharm, Dept Obstet Gynecol & Neonatol, Bucharest, Romania
[3] Victor Babes Univ Med & Pharm, Dept Surg, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
[4] Victor Babes Univ Med & Pharm, Dept Radiol, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
[5] Univ Med & Pharm Oradea, Dept Obstet Gynecol, Oradea, Romania
[6] Grigore T Popa Univ Med & Pharm, Dept Obstetr Gynecol & Neonatol, 16 Univ Str, Iasi 700115, Romania
[7] Victor Babes Univ Med & Pharm, Dept Genet, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
[8] Victor Babes Univ Med & Pharm, Dept Endocrinol, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
来源：
REVISTA DE CHIMIE | 2017年 / 68卷 / 12期
关键词：
PAPP-A; free beta hCG; first trimester biochemical markers; aneuploidies; weight; software correction; 2ND-TRIMESTER; 1ST-TRIMESTER;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Values of first trimester biochemical markers (PAPP-A and free b-hCG) concentration are included in aneuploidies risk evaluation algorithm. Since both markers are produced by the fetus and placenta their concentration depends on the volume in which they are dissolved, respectively the weight of the pregnant women. Our study aimed to analyze the influence of maternal weight on first trimester biochemical markers concentration and the ability of the risk calculation software to correct this influence. Pregnancy-associated protein A (PAPP-A) and free beta chorionic gonadotropin hormone (free beta hCG) first trimester sera concentration respectively weight were measured in 1629 pregnant women. First trimester PAPP-A and free beta hCG concentrations inverse correlate with weight of pregnant women rho=-0.33, p<0.0001, respectively rho=-0.18, p<0.0001. Weight of pregnant women inversely correlates with multiple of median (MoM) values of first trimester markers too: rho=-0.38, p<0.0001 (PAPP-A), respectively rho=-0.17, p<0.0001 (free-b-hCG). The software counterbalances the influence of weight on biochemical markers values. PAPP-A corrected MoM (MoMc) values don't inversely correlate with the weight (rho=-0.03, p=0.12), whereas free beta hCG MoMc values showed an extremely weak inverse correlation (rho=-0.08, p=0.0008). The software counterbalances the influence of weight on PAPP-A values, whereas an extremely weak but insignificant inverse correlation between weight and free-beta hCG values persists after correction.
引用
收藏
页码：2836 / 2838
页数：3
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