Formation of DNA adducts using nickel(II) complexes of redox-active ligands: a comparison of salen and peptide complexes

被引：92
|
作者：
Muller, JG
Kayser, LA
Paikoff, SJ
Duarte, V
Tang, N
Perez, RJ
Rokita, SE
Burrows, CJ [1 ]
机构：
[1] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA
[2] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA
[3] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20792 USA
来源：
COORDINATION CHEMISTRY REVIEWS | 1999年 / 185-6卷
关键词：
nickel; salen; peptides; DNA; oxidation;
D O I：
10.1016/S0010-8545(99)00043-0
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of water-soluble Ni(salen) complexes have been synthesized and studied under oxidative conditions with DNA. Experiments involving gel electrophoretic analysis, substituent effect studies, and mass spectral characterization point to the formation of covalent adducts of the salen ligand with guanine nucleobases. The mechanism of this novel reactivity of transition metal complexes with nucleic acids is discussed in comparison with nickel(II) complexes of peptides and other ligands. (C) 1999 Elsevier Science S.A. All rights reserved.
引用
收藏
页码：761 / 774
页数：14
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