Synthesis of new chiral [2-(1-hydroxyalkyl)pyrrolidino]methylferrocenes and application to the catalytic asymmetric addition of diethylzinc to arylaldehydes

被引：5

作者：

Xu, CL ^{[1
]}

Wang, MC ^{[1
]}

Hou, XH ^{[1
]}

Liu, HM ^{[1
]}

Wang, DH ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Chem, Zhengzhou 450052, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2005年 / 23卷 / 10期

关键词：

chiral [2-(1-hydroxyalkyl)pyrrolidino]methylferrocene; synthesis; asymmetric addition; diethylzinc; arylaldehyde;

D O I：

10.1002/cjoc.200591443

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of new optically active [2-(1-hydroxyalkyl)pyrrolidino]methylferrocenes were conveniently prepared from commercially available L-proline and ferrocenecarboxylic acid. The crystal structure of key intermediate was obtained. They were then applied to catalyze enantioselective addition of diethylzinc to arylaldehydes with enantioselectivity up to 99%. The effects of the ligand structures on the enantioselectivity were also studied.

引用

页码：1443 / 1448

页数：6

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