A new dimeric diarylheptanoid from the rhizomes of Alpinia officinarum

被引：12

作者：

Liu Dan ^{[1
]}

Qu Wei ^{[1
]}

Zhao Ling ^{[2
]}

Guan Fu-Qin ^{[3
,4
]}

Liang Jing-Yu ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Jiangsu, Peoples R China

[2] Wuhan Polytech Univ, Coll Biotechnol & Pharmaceut Engn, Wuhan 430023, Peoples R China

[3] Inst Bot, Nanjing 210014, Jiangsu, Peoples R China

[4] Chinese Acad Sci, Nanjing 210014, Jiangsu, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2014年 / 12卷 / 02期

关键词：

Alpinia officinarum Hance; diarylheptanoid; alpinin B; 1,7-diphenyl-3,5-heptanedione; (4E)-1,7-diphenylhept-4-en-3-one;

D O I：

10.1016/S1875-5364(14)60022-4

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

AIM: To study the chemical constituents of the rhizomes of Alpinia officinarum Hance. METHOD: Compounds were isolated by repeated column chromatography, and their structures were elucidated on the basis of spectral analysis. The cytotoxic activities of these compounds were evaluated with the T98G and B16F10 cell lines by the MTT assay. RESULTS: A dimeric diarylheptanoid, named alpinin B (1), along with three known diarylheptanoids were obtained, and their structures were identified as alpinin B (1), 1, 7-diphenyl-3,5-heptanedione (2), (4E)-1, 7-diphenylhept-4-en-3-one (3) and (4E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one (4). CONCLUSION: Compound 1 is a new dimeric diarylheptanoid. The biosynthetic pathway of 1 was speculated to originate from a Michael reaction between compounds 2 and 3. Compound 3 showed cytotoxicity against the human glioblastoma T98G cell line with IC50 of 27 mu mol.L-1.

引用

页码：139 / 141

页数：3

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