PEHSQMBC: Simultaneous measurement of proton-proton and proton-carbon coupling constants

被引：12

作者：

Sauri, Josep ^{[1
]}

Nolis, Pau ^{[1
]}

Castanar, Laura ^{[1
,2
]}

Virgili, Albert ^{[2
]}

Parella, Teodor ^{[1
,2
]}

机构：

[1] Univ Autonoma Barcelona, Serv Ressonancia Magnet Nucl, E-08193 Barcelona, Spain

[2] Univ Autonoma Barcelona, Dept Quim, E-08193 Barcelona, Spain

来源：

JOURNAL OF MAGNETIC RESONANCE | 2012年 / 224卷

关键词：

HSQMBC; E.COSY; Proton-proton coupling constants; Long-range proton-carbon coupling; constants; IPAP; RESIDUAL DIPOLAR COUPLINGS; ONE-BOND; ACCURATE MEASUREMENT; NMR EXPERIMENTS; SMALL MOLECULES; SPECTROSCOPY; MULTIPLETS; INADEQUATE; SPECTRA; SCALAR;

D O I：

10.1016/j.jmr.2012.09.007

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A long-range optimized P.E.HSQC experiment, named P.E.HSQMBC, is proposed for the simultaneous measurement of a complete set of homonuclear and heteronuclear coupling constants from a single 2D cross-peak. The sign and the magnitude of proton-proton coupling constants are measured along the direct dimension from the relative E.COSY-type multiplet pattern displacement due to the passive one-bond coupling constant splitting generated in the indirect dimension. On the other hand, long-range proton-carbon coupling constants are independently determined in the detected dimension from a traditional fitting analysis of antiphase multiplet patterns or, more conveniently, from the IPAP multiplet displacement obtained from extended HsQMBC experiments. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：101 / 106

页数：6

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