Bioactive 7-Oxabicyclic[6.3.0]lactam and 12-Membered Macrolides from a Gorgonian-Derived Cladosporium sp Fungus

被引：31
|
作者：
Cao, Fei [1 ]
Yang, Qin [2 ,3 ]
Shao, Chang-Lun [1 ]
Kong, Chui-Jian [1 ]
Zheng, Juan-Juan [1 ]
Liu, Yun-Feng [1 ]
Wang, Chang-Yun [1 ]
机构：
[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ China, Qingdao 266003, Peoples R China
[2] Hebei Univ, Chinese Ctr Chiral, Key Lab Med Chem & Mol Diag, Minist Educ, Baoding 071002, Peoples R China
[3] Hebei Univ, Coll Pharm Sci, Baoding 071002, Peoples R China
来源：
MARINE DRUGS | 2015年 / 13卷 / 07期
基金：
中国国家自然科学基金;
关键词：
gorgonian-derived fungus; Cladosporium sp; bicyclic lactam; 12-membered macrolides; cytotoxic activity; ABSOLUTE-CONFIGURATION; GROWTH; ASSAY;
D O I：
10.3390/md13074171
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
One new bicyclic lactam, cladosporilactam A (1), and six known 12-membered macrolides (2-7) were isolated from a gorgonian-derived Cladosporium sp. fungus collected from the South China Sea. Their complete structural assignments were elucidated by comprehensive spectroscopic investigation. Quantum chemistry calculations were used in support of the structural determination of 1. The absolute configuration of 1 was determined by calculation of its optical rotation. Cladosporilactam A (1) was the first example of 7-oxabicyclic[6.3.0]lactam obtained from a natural source. Compound 1 exhibited promising cytotoxic activity against cervical cancer HeLa cell line with an IC50 value of 0.76 M.
引用
收藏
页码：4171 / 4178
页数：8
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