A new antiviral pregnane from a gorgonian-derived Cladosporium sp fungus

被引：26
|
作者：
Yu, Mei-Lin [1 ,2 ]
Guan, Fei-Fei [1 ,2 ]
Cao, Fei [1 ,3 ]
Jia, Yan-Lai [1 ,2 ]
Wang, Chang-Yun [1 ,2 ]
机构：
[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ China, Qingdao, Peoples R China
[2] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China
[3] Hebei Univ, Coll Pharmaceut Sci, Key Lab Pharmaceut Qual Control Hebei Prov, Baoding, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Cladosporium sp; gorgonian Dichotella gemmacea; 3-OH pregnane; structure elucidation; antiviral activity; DERIVATIVES; STRAIN;
D O I：
10.1080/14786419.2017.1342086
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new pregnane, 3-hydroxy-7-ene-6,20-dione (1), and five known steroids (2-6), along with one known steroidal glycoside (7) were obtained from the fungus Cladosporium sp. WZ-2008-0042 cultured from a gorgonian Dichotella gemmacea collected from the South China Sea. The structure and absolute configuration of the new compound (1) were elucidated by comprehensive spectroscopic data and X-ray diffraction data. The compound has a rare configuration of 3-OH that is different from most of pregnanes. All of the isolated compounds were evaluated for their antiviral activities against respiratory syncytial virus (RSV). Among them, 1 exhibited potential antiviral activity with the IC50 value of 0.12mM. [GRAPHICS]
引用
收藏
页码：1260 / 1266
页数：7
相关论文
共 50 条
  • [1] A new hexahydrobenzopyran derivative from the gorgonian-derived Fungus Eutypella sp
    Liao, Hai-Xia
    Sun, Da-Wei
    Zheng, Cai-Juan
    Wang, Chang-Yun
    NATURAL PRODUCT RESEARCH, 2017, 31 (14) : 1640 - 1646
  • [2] New Fatty Acid From a Gorgonian-Derived Xylaria sp Fungus
    Sun, Da-Wei
    Cao, Fei
    Liu, Min
    Guan, Fei-Fei
    Wang, Chang-Yun
    CHEMISTRY OF NATURAL COMPOUNDS, 2017, 53 (02) : 227 - 230
  • [3] Antiviral peptides from marine gorgonian-derived fungus Aspergillus sp SCSIO 41501
    Ma, Xuan
    Nong, Xu-Hua
    Ren, Zhe
    Wang, Jie
    Liang, Xiao
    Wang, Lu
    Qi, Shu-Hua
    TETRAHEDRON LETTERS, 2017, 58 (12) : 1151 - 1155
  • [4] New Fatty Acid From a Gorgonian-Derived Xylaria sp. Fungus
    Da-Wei Sun
    Fei Cao
    Min Liu
    Fei-Fei Guan
    Chang-Yun Wang
    Chemistry of Natural Compounds, 2017, 53 : 227 - 230
  • [5] A NEW ANTHRAQUINONE DERIVATIVE FROM A GORGONIAN-DERIVED FUNGUS Aspergillus sp.
    Chen, Min
    Shao, Chang-Lun
    Kong, Chui-Jian
    She, Zhi-Gang
    Wang, Chang-Yun
    CHEMISTRY OF NATURAL COMPOUNDS, 2014, 50 (04) : 617 - 620
  • [6] A New Anthraquinone Derivative from a Gorgonian-Derived Fungus Aspergillus sp.
    Min Chen
    Chang-Lun Shao
    Chui-Jian Kong
    Zhi-Gang She
    Chang-Yun Wang
    Chemistry of Natural Compounds, 2014, 50 : 617 - 620
  • [7] New cyclic tetrapeptides and asteltoxins from gorgonian-derived fungus Aspergillus sp SCSGAF 0076
    Bao, Jie
    Zhang, Xiao-Yong
    Xu, Xin-Ya
    He, Fei
    Nong, Xu-Hua
    Qi, Shu-Hua
    TETRAHEDRON, 2013, 69 (09) : 2113 - 2117
  • [8] Secondary Metabolites Isolated from the Gorgonian-Derived Fungus Aspergillus ruber and Their Antiviral Activity
    Liang, Ting-Mei
    Fang, Yao-Wei
    Zheng, Ji-Yong
    Shao, Chang-Lun
    CHEMISTRY OF NATURAL COMPOUNDS, 2018, 54 (03) : 559 - 561
  • [9] Secondary Metabolites Isolated from the Gorgonian-Derived Fungus Aspergillus ruber and Their Antiviral Activity
    Ting-Mei Liang
    Yao-Wei Fang
    Ji-Yong Zheng
    Chang-Lun Shao
    Chemistry of Natural Compounds, 2018, 54 : 559 - 561
  • [10] Microketides A and B, Polyketides from a Gorgonian-Derived Microsphaeropsis sp. Fungus
    Liu, Yun-Feng
    Zhang, Ya-Hui
    Shao, Chang-Lun
    Cao, Fei
    Wang, Chang-Yun
    JOURNAL OF NATURAL PRODUCTS, 2020, 83 (04): : 1300 - 1304
12345