A new antiviral pregnane from a gorgonian-derived Cladosporium sp fungus

被引：26

作者：

Yu, Mei-Lin ^{[1
,2
]}

Guan, Fei-Fei ^{[1
,2
]}

Cao, Fei ^{[1
,3
]}

Jia, Yan-Lai ^{[1
,2
]}

Wang, Chang-Yun ^{[1
,2
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ China, Qingdao, Peoples R China

[2] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China

[3] Hebei Univ, Coll Pharmaceut Sci, Key Lab Pharmaceut Qual Control Hebei Prov, Baoding, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Cladosporium sp; gorgonian Dichotella gemmacea; 3-OH pregnane; structure elucidation; antiviral activity; DERIVATIVES; STRAIN;

D O I：

10.1080/14786419.2017.1342086

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new pregnane, 3-hydroxy-7-ene-6,20-dione (1), and five known steroids (2-6), along with one known steroidal glycoside (7) were obtained from the fungus Cladosporium sp. WZ-2008-0042 cultured from a gorgonian Dichotella gemmacea collected from the South China Sea. The structure and absolute configuration of the new compound (1) were elucidated by comprehensive spectroscopic data and X-ray diffraction data. The compound has a rare configuration of 3-OH that is different from most of pregnanes. All of the isolated compounds were evaluated for their antiviral activities against respiratory syncytial virus (RSV). Among them, 1 exhibited potential antiviral activity with the IC50 value of 0.12mM. [GRAPHICS]

引用

页码：1260 / 1266

页数：7

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