Sensitivity of peripheral blood lymphocytes from breast cancer patients to glucocorticoids

被引：1

作者：

Ioannesyants, IA ^{[1
]}

Polevaya, EB ^{[1
]}

机构：

[1] Russian Acad Sci, NN Blokhin Russian Oncol Ctr, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2006年 / 141卷 / 01期

关键词：

glucocorticoids; lymphocytes; breast cancer;

D O I：

10.1007/s10517-006-0097-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We measured DNA-dependent RNA polymerase activity, calculated hormone-binding sites and intracellular association constant under conditions of phytohemagglutinin stimulation and dexamethasone treatment, and studied the interaction of cells with the glucocorticoid covalently bound to an inert carrier not penetrating into cells. Reduced sensitivity of peripheral blood lymphocytes from breast cancer patients to glucocorticoids was demonstrated. The biological mechanisms for hormonal regulation are reviewed here.

引用

页码：73 / 76

页数：4

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