Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

被引：23
|
作者：
Shang, Li [1 ,2 ]
Wang, Mingrong [1 ,2 ]
机构：
[1] Peking Union Med Coll, Canc Inst Hosp, State Key Lab Mol Oncol, Beijing 100021, Peoples R China
[2] Chinese Acad Med Sci, Beijing 100021, Peoples R China
来源：
FRONTIERS OF MEDICINE | 2013年 / 7卷 / 04期
基金：
国家高技术研究发展计划(863计划);
关键词：
esophageal squamous cell carcinoma (ESCC); early detection; molecular classification; molecular markers; ENDOTHELIAL-GROWTH-FACTOR; POOR-PROGNOSIS; POTENTIAL BIOMARKER; PRB EXPRESSION; HIGH-RISK; EPIGENETIC INACTIVATION; P53; PROTEIN; E-CADHERIN; CYCLIN D1; CANCER;
D O I：
10.1007/s11684-013-0286-y
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Esophageal squamous cell carcinoma (ESCC) is one of the most common types of gastrointestinal cancers, and the fourth leading cause of cancer-related deaths in China. Early detection and intervention in time may dramatically increase the survival of the patients by initiating treatment regimens during earlier stages of ESCC or even during precancerous stages. Molecular classification will be useful for subtyping esophageal tumors or precancerous lesions to improve current therapeutics or early intervention of the disease. In this review, we summarize the findings in investigating the molecular alterations and clinical relevance of ESCC.
引用
收藏
页码：401 / 410
页数：10
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