Reinvestigation of tryptophan-dehydrobutyrine diketopiperazine structure

被引：9
|
作者：
Avendaño, C [1 ]
Cabezas, N [1 ]
de la Cuesta, E [1 ]
González, JF [1 ]
机构：
[1] Univ Complutense, Fac Farm, Dept Quim Organ & Farmaceut, E-28040 Madrid, Spain
来源：
ARKIVOC | 2005年
关键词：
piperazinediones; TDD; N-acetylation; aldol; type condensation;
D O I：
10.3998/ark.5550190.0006.905
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reinvestigation of the title natural product's structure ( 1) has shown the easy racemization of the Trp-stereocenter in some derivatives of cyclo-L-Trp-Gly. The here described synthesis of compound 2, a regioisomer of 1 with the N-methyl group on the nitrogen adjacent to the ethylidene side-chain, permits us to conclude that structure 1 was correct.
引用
收藏
页码：30 / 38
页数：9
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