Synthesis and Antioxidant Activity of New Pyrazolo[1,5-a]Pyrimidine Derivatives Incorporating a Thiazol-2-yldiazenyl Moiety

被引：10
|
作者：
El-Mekabaty, Ahmed [1 ]
Habib, Osman M. O. [1 ]
Moawad, Evelin B. [1 ]
Hasel, Ali M. [1 ]
机构：
[1] Mansoura Univ, Dept Chem, Fac Sci, El Gomhoria St, ET-35516 Mansoura, Egypt
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2016年 / 53卷 / 06期
关键词：
FACILE SYNTHESIS; DISAZO DYES; AGENTS;
D O I：
10.1002/jhet.2492
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
4-(Thiazol-2-yldiazenyl)-1H-pyrazole-3,5-diamine (2) was prepared by the reaction of 2-thiazolylazomalononitrile (1) with hydrazine hydrate in boiling ethanol and used as key intermediate for the synthesis of polyfunctionally substitut ed pyrazolo[1,5-a]pyrimidines via its reactions with reagents having 1,3-dielectrophilic centers. Structures of the newly synthesized compounds were established by elemental analysis and spectral data. Representative compounds of the synthesized products were tested and evaluated as antioxidant agents. The results revealed that compounds (3), (4), (5), and (9) displayed promising antioxidant activity compared to the activity of ascorbic acid.
引用
收藏
页码：1820 / 1826
页数：7
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