Cell biology of infection by Legionella pneumophila

被引：57
|
作者：
Xu, Li [1 ]
Luo, Zhao-Qing [1 ]
机构：
[1] Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA
来源：
MICROBES AND INFECTION | 2013年 / 15卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Intracellular pathogens; Vesicle trafficking; Type IV secretion; Effectors; Host function subversion; NUCLEOTIDE EXCHANGE FACTOR; EFFECTOR PROTEIN DRRA; E3 UBIQUITIN LIGASE; RAB GTPASE FUNCTION; ENDOPLASMIC-RETICULUM; LEGIONNAIRES-DISEASE; VIRULENCE SYSTEM; PLASMA-MEMBRANE; GENE DELETION; HOST;
D O I：
10.1016/j.micinf.2012.11.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Professional phagocytes digest internalized microorganisms by actively delivering them into the phagolysosomal compartment. Intravacuolar bacterial pathogens have evolved a variety of effective strategies to bypass the default pathway of phagosomal maturation to create a niche permissive for their survival and propagation. Here we discuss recent progress in our understanding of the sophisticated mechanisms used by Legionella pneumophila to survive in phagocytes. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：157 / 167
页数：11
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