The role of choline in prostate cancer

被引：70

作者：

Awwad, Hussain Mohamad ^{[1
]}

Geisel, Juergen ^{[1
]}

Obeid, Rima ^{[1
]}

机构：

[1] Saarland Univ Hosp, Dept Clin Chem & Lab Med, D-66421 Homburg, Germany

来源：

CLINICAL BIOCHEMISTRY | 2012年 / 45卷 / 18期

关键词：

Choline; Methyl; Prostate cancer; Phospholipids; ONE-CARBON METABOLISM; GSTP1 CPG ISLAND; PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE; PHOSPHOLIPASE-D; BREAST-CANCER; CELL-PROLIFERATION; DIETARY CHOLINE; RAS PROTEINS; C-JUN; KINASE;

D O I：

10.1016/j.clinbiochem.2012.08.012

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Choline is an essential nutrient that is necessary for cell membrane synthesis and phospholipid metabolism and functions as an important methyl donor. Multiple roles for choline in cancer development have been suggested. Choline can affect DNA methylation and lead to a disruption of DNA repair. It can also modify cell signaling that is mediated by intermediary phospholipid metabolites, and it can support the synthesis of cell membranes and thus support cell proliferation. A higher intake or status of choline in plasma and tissues has been related to higher cancer risks. Prostate cancer shows elevated levels of choline uptake and levels of certain choline metabolites. Choline metabolites can be used as potential prognostic biomarkers for the management of prostate cancer patients. Targeting certain enzymes, which are related to choline metabolism, provides promising therapeutic opportunities for tumor growth arrest. This review summarizes the potential role of choline metabolism in cancer, especially in prostate cancer. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1548 / 1553

页数：6

共 50 条

[21] CHOLINE AS A PET TRACER FOR DETECTION OF MALIGNANCY IN PROSTATE CANCER
Kley, K.
Oehr, P.
ANTICANCER RESEARCH, 2008, 28 (6B) : 4045 - 4046
[22] PET Imaging of Prostate Cancer Using Radiolabeled Choline
Beheshti, Mohsen
Langsteger, Werner
PET CLINICS, 2009, 4 (02) : 173 - +
[23] Is there a place of TEP choline in the initial management of prostate cancer?
Brenot-Rossi, I.
MEDECINE NUCLEAIRE-IMAGERIE FONCTIONNELLE ET METABOLIQUE, 2013, 37 (08): : 329 - 332
[24] Current status of choline-PET and prostate cancer
Taylor, Benjamin P.
Kirby, Roger
Hughes, Simon
Chowdhury, Simon
Payne, Heather
Cook, Gary J. R.
TRENDS IN UROLOGY & MENS HEALTH, 2014, 5 (03) : 34 - 37
[25] Transcriptome foundations of choline and acetate uptake in prostate cancer
Wang, Xiaofei
Wahl, Richard
JOURNAL OF NUCLEAR MEDICINE, 2009, 50
[26] Role of 11C choline PET/CT in the management of prostate cancer patients with biochemical relapse
Frakulli, R.
Siepe, G.
Ntreta, M.
Cammelli, S.
Tolento, G.
Macchia, G.
Deodato, F.
Arcelli, A.
Bertini, F.
Ronchi, L.
Di Gioia, G.
Dionisi, V.
Pieri, M.
Martorana, G.
Fanti, S.
Balestrini, D.
Degli Esposti, C.
Galuppi, A.
Morganti, A. G.
Frezza, G.
RADIOTHERAPY AND ONCOLOGY, 2016, 119 : S640 - S640
[27] Role of 11C-choline PET/CT in radiation therapy planning of patients with prostate cancer
D'Agostino, Giuseppe R.
Lopci, Egesta
Di Brina, Lucia
Franzese, Ciro
Tomatis, Stefano
Castello, Angelo
Franceschini, Davide
Navarria, Pierina
Chiti, Arturo
Scorsetti, Marta
NUCLEAR MEDICINE COMMUNICATIONS, 2018, 39 (10) : 951 - 956
[28] High risk and very high risk prostate cancer and the role of choline PET/CT at initial staging
Evangelista, L.
Zattoni, F.
Guttilla, A.
Cervino, A.
Gregianin, M.
Burei, M.
Zattoni, F.
Saladini, G.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2013, 40 : S366 - S366
[29] Role of 11C-CHOLINE PET/CT in the Radiotherapy Treatment Planning of Prostate Cancer Patients
Lopci, E.
D'Agostino, G. R.
Franzese, C.
Villa, E.
Rodari, M.
Scorsetti, M.
Chiti, A.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2015, 42 : S268 - S269
[30] Choline PET/CT for detecting of local recurrence in prostate cancer
Bottke, D.
Fels, F.
Bartkowiak, D.
Glatting, G.
Reske, S.
Wiegel, T.
ONKOLOGIE, 2010, 33 : 103 - 103

← 1 2 3 4 5 →