A highly efficient synthesis of 3H-1,5-benzodiazepine derivatives using lanthanum(III) nitrate hexahydrate as a catalyst

被引：0
|
作者：
Kumar, Rajesh [1 ]
Joshi, Y. C. [1 ]
机构：
[1] Univ Rajasthan, Dept Chem, Jaipur 302004, Rajasthan, India
来源：
JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2008年 / 85卷 / 10期
关键词：
Lanthanum(III) nitrate hexahydrate; 3H-1,5-benzodiazepines; beta-diketones; beta-ketoesters; pyrazolo[4,3-d]pyrimidin-7-one;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sulphonation of 5-(2-ethoxyphenyl)-l-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (1) with chlorosulphonic acid affords 5-[(5-chlorosulphonyl-2-ethoxy)pyrimidin]-l-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (2). Compound (2) condensed with different beta-diketones/beta-ketoesters (3a-e) to obtain new beta-diketones/beta-ketoesters (4a-e). These beta-diketones/beta-ketoesters were condensed with o-phenylenediamine (o-PDA) in presence of lanthanum(III) nitrate hexahydrate to afford biologically active 3H-1,5-benzodiazepines (5a-e) in excellent yield. The compounds (5a-e) have been screened for antimicrobial, antifungal and anthelmintic activities.
引用
收藏
页码：1045 / 1049
页数：5
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