A highly efficient synthesis of 3H-1,5-benzodiazepine derivatives using lanthanum(III) nitrate hexahydrate as a catalyst

被引：0

作者：

Kumar, Rajesh ^{[1
]}

Joshi, Y. C. ^{[1
]}

机构：

[1] Univ Rajasthan, Dept Chem, Jaipur 302004, Rajasthan, India

来源：

JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2008年 / 85卷 / 10期

关键词：

Lanthanum(III) nitrate hexahydrate; 3H-1,5-benzodiazepines; beta-diketones; beta-ketoesters; pyrazolo[4,3-d]pyrimidin-7-one;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sulphonation of 5-(2-ethoxyphenyl)-l-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (1) with chlorosulphonic acid affords 5-[(5-chlorosulphonyl-2-ethoxy)pyrimidin]-l-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (2). Compound (2) condensed with different beta-diketones/beta-ketoesters (3a-e) to obtain new beta-diketones/beta-ketoesters (4a-e). These beta-diketones/beta-ketoesters were condensed with o-phenylenediamine (o-PDA) in presence of lanthanum(III) nitrate hexahydrate to afford biologically active 3H-1,5-benzodiazepines (5a-e) in excellent yield. The compounds (5a-e) have been screened for antimicrobial, antifungal and anthelmintic activities.

引用

页码：1045 / 1049

页数：5

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