TWO NEW Co(II)-BASED COORDINATION POLYMERS: CRYSTAL STRUCTURES AND THE LOCAL ANALGESIA ACTIVITY DUE TO REDUCING LOCAL ACETYLCHOLINE CONTENTS

Two new Co(II)-based coordination polymers {[Co(L)](DMF)}(n)(1, H2L = 5-(1H-imidazol-1-yl)isophthalic acid) and {[Co-2(L)(2)(H2O)]center dot 3H(2)O}(n)(2) are successfully synthesized by the hydrothermal or solvothermal method. The resulting single crystal X-ray diffraction studies demonstrate that complex1presents a 3D 3,6-connected framework with a binuclear Co(II) paddle-wheel cluster as the secondary building unit, while complex2displays a 3,3,4,8-connected 3D network structure with the a trinuclear linear Co-3(CO2)(6)cluster as the secondary building unit. The in vivo local anesthesia activity of compounds1and2is evaluated via the mice hot plate analgesic experiment. Then, the local content of acetylcholine in mice is measured by the ELISA assay.