LC Enantioseparation of β-Amino Acids on a Crown Ether-Based Stationary Phase

被引：10

作者：

Berkecz, Robert ^{[1
]}

Ilisz, Istvan ^{[1
]}

Patai, Zoltan ^{[1
]}

Fueloep, Ferenc ^{[2
]}

Choi, Hee Jung ^{[3
,4
]}

Hyun, Myung Ho ^{[3
,4
]}

Peter, Antal ^{[1
]}

机构：

[1] Univ Szeged, Dept Inorgan & Analyt Chem, H-6720 Szeged, Hungary

[2] Univ Szeged, Inst Pharmaceut Chem, H-6720 Szeged, Hungary

[3] Pusan Natl Univ, Dept Chem, Pusan 609735, South Korea

[4] Pusan Natl Univ, Chem Inst Funct Mat, Pusan 609735, South Korea

来源：

CHROMATOGRAPHIA | 2008年 / 68卷 / Suppl 1期

关键词：

Column liquid chromatography; beta-3-Homo-amino acids; (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic acid-based chiral stationary phase;

D O I：

10.1365/s10337-007-0498-x

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Reversed-phase high-performance liquid chromatographic methods were developed for the enantioseparation of ten unusual beta-3-homo-amino acids. The underivatized analytes were separated on a chiral stationary phase containing (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid as chiral selector. The effects of organic and acidic modifiers and the mobile phase composition on the separation were investigated. The structures of the substituents in the beta position substantially influenced the retention and resolution. The elution sequence was determined in some cases: the S enantiomers eluted before the R enantiomers.

引用

页码：S13 / S18

页数：6

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