Genetic diversity of HLA system in six populations from Mexico City Metropolitan Area, Mexico: Mexico City North, Mexico City South, Mexico City East, Mexico City West, Mexico City Center and rural Mexico City

被引：4

作者：

Barquera, Rodrigo ^{[1
,2
]}

Cesar Martinez-Alvarez, Julio ^{[3
]}

Iraiz Hernandez-Zaragoza, Diana ^{[2
,4
]}

Bravo-Acevedo, Alicia ^{[5
]}

Juarez-Nicolas, Francisco ^{[6
]}

Jerico Arriaga-Perea, Agustin ^{[7
]}

del Rosario Vega-Martinez, Maria ^{[8
]}

Ortega-Yanez, Andrea ^{[9
]}

Benitez-Arvizu, Gamaliel ^{[10
]}

Arrieta-Bolanos, Esteban ^{[11
]}

Clayton, Stephen ^{[1
]}

Dolores Juarez-Cortes, Eva ^{[7
]}

Lopez-Gil, Concepcion ^{[12
]}

Garcia-Alvarez, Raquel ^{[13
]}

Araceli Arrazola-Garcia, Maria ^{[3
]}

Martinez-Bezies, Virginia ^{[14
]}

Juarez-Barreto, Vicencio ^{[15
]}

del Rocio Ramos-de la Cruz, Flor ^{[12
]}

Maria Macias-Medrano, Rosa ^{[7
]}

Mendez-Mani, Patricia ^{[12
]}

Escutia-Gonzalez, Ariadna ^{[6
]}

Daniel Montiel-Hernandez, Gustavo ^{[16
]}

Immel, Alexander ^{[1
,17
]}

de los Angeles Pavon-Vargas, Maria ^{[12
]}

Salgado-Galicia, Norma ^{[8
]}

Novelo-Garza, Barbara ^{[18
]}

Zuniga, Joaquin ^{[19
,20
]}

Yunis, Edmond J. ^{[21
]}

Bekker-Mendez, Carolina ^{[22
]}

Granados, Julio ^{[23
]}

机构：

[1] Max Planck Inst Sci Human Hist, Dept Archaeogenet, Kahla Str 10, D-07745 Jena, Germany

[2] Escuela Nacl Antropol & Hist ENAH, Mol Genet Lab, Mexico City, DF, Mexico

[3] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Siglo XXI, Unidad Med Alta Especialidad UMAE, Hosp Especialidades,Cent Blood Bank,HLA Lab, Mexico City, DF, Mexico

[4] Tecn Genet Aplicadas Clin TGAC, Immunogenet Unit, Mexico City, DF, Mexico

[5] Inst Mexicano Seguro Social IMSS, UMAE Hosp Gineco Obstet 4 Luis Castelasso Ayala, Blood Bank, Mexico City, DF, Mexico

[6] Inst Nacl Pediat INP, Mol Immunogenet Lab, Mexico City, DF, Mexico

[7] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl La Raza, Cent Blood Bank, Histocompatibil Lab, Mexico City, DF, Mexico

[8] Petr Mexicanos PEMEX, Hosp Cent Sur Alta Especialidad, Mol Biol & Histocompatibil Lab, Mexico City, DF, Mexico

[9] Univ Nacl Autonoma Mexico, Inst Biotecnol IBT, Dept Dev Genet & Mol Physiol, Cuernavaca, Morelos, Mexico

[10] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Siglo XXI, Unidad Med Alta Especialidad UMAE, Hosp Especialidades,Cent Blood Bank, Mexico City, DF, Mexico

[11] Univ Hosp Essen, Inst Expt Cellular Therapy, Essen, Germany

[12] Inst Mexicano Seguro Social IMSS, Unidad Med Alta Especialidad UMAE 6, Histocompatibil Lab, Puebla, Mexico

[13] Inst Nacl Pediat INP, Res Unit, Pharmacol Lab, Mexico City, DF, Mexico

[14] Qualth Med Syst Lab, Mexico City, DF, Mexico

[15] Hosp Infantil Mexico Dr Federico Gomez, Blood Bank, Mexico City, DF, Mexico

[16] Escuela Nacl Antropol & Hist ENAH, Mexico City, DF, Mexico

[17] Univ Kiel, Univ Hosp, Inst Clin Mol Biol IKMB, Schleswig Holstein, Germany

[18] Inst Mexicano Seguro Social IMSS, Med Infrastruct Planning Comm, Mexico City, DF, Mexico

[19] Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Lab Immunobiol & Genet, Mexico City, DF, Mexico

[20] Tecnol Monterrey, Escuela Med & Ciencias Salud, Mexico City, DF, Mexico

[21] Dana Farber Canc Inst, Dept Canc Immunol & Virol, Boston, MA 02115 USA

[22] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl La Raza, Infectol Hosp, Immunol & Infectol Res Unit, Mexico City, DF, Mexico

[23] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Transplantat, Mexico City, DF, Mexico

来源：

HUMAN IMMUNOLOGY | 2020年 / 81卷 / 09期

关键词：

HLA; Immunogenetics; Population genetics; Mexico City; Mexico City Metropolitan Area; Admixture; DIFFERENTIATION; URBAN; FREQUENCIES; MIGRATION; ADMIXTURE;

D O I：

10.1016/j.humimm.2019.07.297

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 1217 Mexicans from the Mexico City Metropolitan Area living in the northern (N = 751), southern (N = 52), eastern (N = 79), western (N = 33), and central (N = 152) Mexico City, and rural communities (N = 150), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes include 11 Native American haplotypes. Admixture estimates revealed that the main genetic components are Native American (63.85 +/- 1.55% by ML; 57.19% of Native American haplotypes) and European (28.53 +/- 3.13% by ML; 28.40% of European haplotypes), and a less apparent African genetic component (7.61 +/- 1.96% by ML; 7.17% of African haplotypes).

引用

页码：539 / 543

页数：5

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