Synthesis and characterization of poly(L-lysine-co-L-proline) as a non-viral gene delivery vector

被引：5

作者：

Lee, SJ

Ahn, CH ^{[1
]}

Ko, JH

Chae, SY

Lee, M

机构：

[1] Seoul Natl Univ, Sch Mat Sci & Engn, HOMRC, Seoul 151744, South Korea

[2] Korean Minjok Leadership Acad, Hoengsung 225823, Gangwon, South Korea

[3] Sunchon Natl Univ, Dept Polymer Sci & Engn, Sunchon 540742, Jeonnam, South Korea

[4] Hanyang Univ, Coll Engn, Dept Bioengn, Seoul 133791, South Korea

来源：

MACROMOLECULAR RESEARCH | 2006年 / 14卷 / 02期

关键词：

D O I：

10.1007/BF03218499

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Copolymers based on lysine and proline were synthesized by the ring-opening polymerization of corresponding α-amino acid N-carboxy anhydrides. In vitro cytotoxicity and transfection efficiency were measured on 293T cell line. Copolymers displayed a four-fold improvement in transfection efficiency compared with that of PLL homopolymer. Cytotoxicity of the copolymers was almost negligible and slightly increased with increasing amount of proline residues in the copolymers.

引用

页码：129 / 131

页数：3

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