Extracellular Matrix Remodeling and Development of Cancer

被引：41

作者：

Girigoswami, Koyeli ^{[1
]}

Saini, Devender ^{[2
]}

Girigoswami, Agnishwar ^{[1
]}

机构：

[1] Chettinad Acad Res & Educ, Chettinad Hosp & Res Inst, Fac Allied Hlth Sci, Med Bionanotechnol, Kelambakkamtam 603103, Tamil Nadu, India

[2] Chettinad Acad Res & Educ, Chettinad Hosp & Res Inst, Fac Allied Hlth Sci, Tissue Engn & Regenerat Med, Kelambakkam 603103, Tamil Nadu, India

来源：

STEM CELL REVIEWS AND REPORTS | 2021年 / 17卷 / 03期

关键词：

Extracellular matrix; Stiffness of ECM; ECM remodeling; Cancer ECM; Cancer niche; CELL-DIFFERENTIATION; KERATAN SULFATE; BINDING-SITES; EXPRESSION; COLLAGEN; PROTEOGLYCANS; ARCHITECTURE; HOMEOSTASIS; METASTASIS; PHENOTYPE;

D O I：

10.1007/s12015-020-10070-1

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The importance of stem cell growth and its fate is highly essential for the use of stem cells in therapy and regeneration. There are conflicting evidences regarding the actual role of stem cells when injected into a patient towards damage recovery and its lifespan inside the body. Tumor microenvironment differs from that of normal cells and may have a role in the growth of stem cells when associated with them. In cancer, the uncontrolled growth of cells remodels the extracellular matrix (ECM). The ECM alteration occurs as the mutated fibroblast cells release growth factors into the ECM which further alters the ECM directly or changes the epithelial cells and then alters the ECM. In this review we will discuss about the components and functions of ECM and how does it differ in cancer cells compared to normal cells. Abnormal dynamics of the ECM and its role in cancer progression will also be discussed.

引用

页码：739 / 747

页数：9

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