Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

被引：24
|
作者：
Liang, Steven H. [1 ,2 ]
Collier, Thomas Lee [1 ,2 ,3 ]
Rotstein, Benjamin H. [1 ,2 ]
Lewis, Rebecca [2 ,4 ]
Steck, Mia [2 ]
Vasdev, Neil [1 ,2 ]
机构：
[1] Harvard Univ, Dept Radiol, Sch Med, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Div Nucl Med & Mol Imaging, Boston, MA 02114 USA
[3] Advion Inc, Ithaca, NY 14850 USA
[4] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 78期
关键词：
PET; KINASE;
D O I：
10.1039/c3cc45166f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We have combined the benefits of both microfluidics and flow hydrogenation to provide facile access to previously underutilized reduction and protecting group chemistries for PET imaging applications. The rapid removal of an O-benzyl protecting group to prepare 2-[F-18] fluoroquinolin-8-ol and the reduction of a nitro group in the synthesis of 4-[F-18] fluoroaniline were achieved within 3 minutes.
引用
收藏
页码：8755 / 8757
页数：3
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