Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine

被引：70
|
作者：
Ma, Zhan-Jun [1 ]
Yang, Jing-Jing [1 ]
Lu, Yu-Bao [1 ]
Liu, Zhao-Yang [2 ]
Wang, Xue-Xi [3 ]
机构：
[1] Lanzhou Univ, Clin Med Coll 2, Lanzhou 730000, Gansu, Peoples R China
[2] Shanxi Med Univ, Dept Med Imaging, Jinzhong 030600, Shaanxi, Peoples R China
[3] Lanzhou Univ, Sch Basic Med Sci, 205 South Tianshui Rd, Lanzhou 730000, Gansu, Peoples R China
来源：
WORLD JOURNAL OF STEM CELLS | 2020年 / 12卷 / 08期
关键词：
Exosomes; Mesenchymal stem cells; Cell-free therapy; Regenerative medicine; Mesenchymal stem cell-derived exosomes; Extracellular vesicles; SPINAL-CORD-INJURY; ISCHEMIA-REPERFUSION INJURY; PROMOTE FUNCTIONAL RECOVERY; BONE-MARROW; STROMAL CELLS; IN-VITRO; MYOCARDIAL-INFARCTION; ADIPOSE-TISSUE; ISCHEMIA/REPERFUSION INJURY; NEUROVASCULAR PLASTICITY;
D O I：
10.4252/wjsc.v12.i8.814
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Mesenchymal stem cells (MSCs) are multipotent stem cells with marked potential for regenerative medicine because of their strong immunosuppressive and regenerative abilities. The therapeutic effects of MSCs are based in part on their secretion of biologically active factors in extracellular vesicles known as exosomes. Exosomes have a diameter of 30-100 nm and mediate intercellular communication and material exchange. MSC-derived exosomes (MSC-Exos) have potential for cell-free therapy for diseases of, for instance, the kidney, liver, heart, nervous system, and musculoskeletal system. Hence, MSC-Exos are an alternative to MSC-based therapy for regenerative medicine. We review MSC-Exos and their therapeutic potential for a variety of diseases and injuries.
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页码：814 / 840
页数：27
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