Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine

被引：71

作者：

Ma, Zhan-Jun ^{[1
]}

Yang, Jing-Jing ^{[1
]}

Lu, Yu-Bao ^{[1
]}

Liu, Zhao-Yang ^{[2
]}

Wang, Xue-Xi ^{[3
]}

机构：

[1] Lanzhou Univ, Clin Med Coll 2, Lanzhou 730000, Gansu, Peoples R China

[2] Shanxi Med Univ, Dept Med Imaging, Jinzhong 030600, Shaanxi, Peoples R China

[3] Lanzhou Univ, Sch Basic Med Sci, 205 South Tianshui Rd, Lanzhou 730000, Gansu, Peoples R China

来源：

WORLD JOURNAL OF STEM CELLS | 2020年 / 12卷 / 08期

关键词：

Exosomes; Mesenchymal stem cells; Cell-free therapy; Regenerative medicine; Mesenchymal stem cell-derived exosomes; Extracellular vesicles; SPINAL-CORD-INJURY; ISCHEMIA-REPERFUSION INJURY; PROMOTE FUNCTIONAL RECOVERY; BONE-MARROW; STROMAL CELLS; IN-VITRO; MYOCARDIAL-INFARCTION; ADIPOSE-TISSUE; ISCHEMIA/REPERFUSION INJURY; NEUROVASCULAR PLASTICITY;

D O I：

10.4252/wjsc.v12.i8.814

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Mesenchymal stem cells (MSCs) are multipotent stem cells with marked potential for regenerative medicine because of their strong immunosuppressive and regenerative abilities. The therapeutic effects of MSCs are based in part on their secretion of biologically active factors in extracellular vesicles known as exosomes. Exosomes have a diameter of 30-100 nm and mediate intercellular communication and material exchange. MSC-derived exosomes (MSC-Exos) have potential for cell-free therapy for diseases of, for instance, the kidney, liver, heart, nervous system, and musculoskeletal system. Hence, MSC-Exos are an alternative to MSC-based therapy for regenerative medicine. We review MSC-Exos and their therapeutic potential for a variety of diseases and injuries.

引用

页码：814 / 840

页数：27

共 50 条

[1] Therapeutic application of mesenchymal stem cell-derived exosomes: A promising cell-free therapeutic strategy in regenerative medicine
Motavaf, M.
Pakravan, K.
Babashah, S.
Malekvandfard, F.
Masoumi, M.
Sadeghizadeh, M.
[J]. CELLULAR AND MOLECULAR BIOLOGY, 2016, 62 (07) : 74 - 79
[2] Mesenchymal Stem Cell-Derived Exosomes: Toward Cell-Free Therapeutic Strategies in Chronic Kidney Disease
Cao, Qinghua
Huang, Chunling
Chen, Xin-Ming
Pollock, Carol A.
[J]. FRONTIERS IN MEDICINE, 2022, 9
[3] Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine
Vizoso, Francisco J.
Eiro, Noemi
Cid, Sandra
Schneider, Jose
Perez-Fernandez, Roman
[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (09)
[4] Therapeutic potential of mesenchymal stem cell-derived exosomes for regenerative medicine applications
Szymon Roszkowski
[J]. Clinical and Experimental Medicine, 24
[5] Therapeutic potential of mesenchymal stem cell-derived exosomes for regenerative medicine applications
Roszkowski, Szymon
[J]. CLINICAL AND EXPERIMENTAL MEDICINE, 2024, 24 (01)
[6] Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine
Hade, Mangesh D.
Suire, Caitlin N.
Suo, Zucai
[J]. CELLS, 2021, 10 (08)
[7] Emerging Role of Mesenchymal Stem Cell-derived Exosomes in Regenerative Medicine
Zhao, Ting
Sun, Feng
Liu, Jinwen
Ding, Tianyan
She, Jie
Mao, Fei
Xu, Wenrong
Qian, Hui
Yan, Yongmin
[J]. CURRENT STEM CELL RESEARCH & THERAPY, 2019, 14 (06) : 482 - 494
[8] Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications
Rani, Sweta
Ryan, Aideen E.
Griffin, Matthew D.
Ritter, Thomas
[J]. MOLECULAR THERAPY, 2015, 23 (05) : 812 - 823
[9] Future perspective of stem cell-derived exosomes: Cell-free therapeutic strategies for retinal degeneration
Liu, Zibin
Zeng, Fang
Zhang, Yao
Liu, Yongqing
Li, Zhuo
Liu, Xiao
[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022, 10
[10] Mesenchymal stem cell-derived exosomes for organ development and cell-free therapy
Shi, Xin
Jiang, Nan
Mao, Jing
Luo, Dan
Liu, Yan
[J]. NANO SELECT, 2021, 2 (07): : 1291 - 1325

← 1 2 3 4 5 →