DNA damage;
progenitor cell;
progeria;
senescence;
telomere;
D O I:
10.1038/ncpcardio1324
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Epidemiological studies have shown that age is the chief risk factor for atherosclerotic cardiovascular diseases, but the molecular mechanisms that underlie the increase in risk conferred by aging remain unclear. Evidence suggests that the cardiovascular repair system is impaired with advancing age, thereby inducing age-associated cardiovascular dysfunction. Such impairment could be attributable to senescence of cardiovascular tissues at the cellular level as a result of telomere shortening, DNA damage, and genomic instability. In fact, the replicative ability of cardiovascular cells, particularly stem cells and/or progenitor cells, has been shown to decline with age. Recently, considerable progress has been made in understanding the pathogenesis of human progeroid syndromes that feature cardiovascular aging. Most of the genes responsible have a role in DNA metabolism, and mutated forms of these genes result in alterations of the response to DNA damage and in decreased cell proliferation, which might be common features of a phenotype of aging. Here we review the cardiovascular research on cellular senescence, stem cell aging, and progeroid syndromes and discuss the potential role of cellular senescence in the mechanisms underlying both normal aging and premature aging syndromes.
机构:
Buck Inst Res Aging, Novato, CA 94945 USABuck Inst Res Aging, Novato, CA 94945 USA
Chinta, Shankar J.
Woods, Georgia
论文数: 0引用数: 0
h-index: 0
机构:
Buck Inst Res Aging, Novato, CA 94945 USABuck Inst Res Aging, Novato, CA 94945 USA
Woods, Georgia
Rane, Anand
论文数: 0引用数: 0
h-index: 0
机构:
Buck Inst Res Aging, Novato, CA 94945 USABuck Inst Res Aging, Novato, CA 94945 USA
Rane, Anand
Demaria, Marco
论文数: 0引用数: 0
h-index: 0
机构:
Buck Inst Res Aging, Novato, CA 94945 USABuck Inst Res Aging, Novato, CA 94945 USA
Demaria, Marco
Campisi, Judith
论文数: 0引用数: 0
h-index: 0
机构:
Buck Inst Res Aging, Novato, CA 94945 USA
Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USABuck Inst Res Aging, Novato, CA 94945 USA
Campisi, Judith
Andersen, Julie K.
论文数: 0引用数: 0
h-index: 0
机构:
Buck Inst Res Aging, Novato, CA 94945 USABuck Inst Res Aging, Novato, CA 94945 USA