The 3020insC Allele of NOD2 Predisposes to Cancers of Multiple Organs

被引：23
|
作者：
Lubinski, Jan [1 ]
Huzarski, Tomasz
Kurzawski, Grzegorz
Suchy, Janina
Masojc, Bartlomiej
Mierzejewski, Marek
Lener, Marcin [2 ]
Domagala, Wenancjusz
Chosia, Maria
Teodorczyk, Urszula
Medrek, Krzysztof
Debniak, Tadeusz
Zlowocka, Elzbieta
Gronwald, Jacek
Byrski, Tomasz
Grabowska, Ewa [2 ]
Nej, Katarzyna [2 ]
Szymanska, Anna
Szymanska, Jolanta
Matyjasik, Joanna
Cybulski, Cezary
Jakubowska, Anna
Gorski, Bohdan
Narod, Steven A. [3 ]
机构：
[1] Pomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, PL-70115 Szczecin, Poland
[2] Univ Szczecin, Interuniv Unit Mol Biol, Szczecin, Poland
[3] Univ Toronto, Ctr Res Womens Hlth, Toronto, ON M5S 1A1, Canada
来源：
HEREDITARY CANCER IN CLINICAL PRACTICE | 2005年 / 3卷 / 2期
关键词：
NOD2; cancer susceptibility; multiple organs;
D O I：
10.1186/1897-4287-3-2-59
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The NOD2 gene has been associated with susceptibility to Crohn's disease and individuals with Crohn's disease are at increased risk for cancer at a number of organ sites. We studied the association between the 3020insC allele of the NOD2 gene and cancer among 2604 cancer patients and 1910 controls from Poland. Patients were diagnosed with one of twelve types of cancer in the Szczecin region between 1994 and 2004. Significant associations were found for colon cancer (OR=1.8; 95% CI 1.2 to 2.6), for lung cancer (OR=1.7; 95% CI=1.1 to 2.5) and for ovarian cancer (OR=1.6; 95% CI 1.1 to 2.3). In addition, a significant association was found for early-onset laryngeal cancer (OR=2.9; 95% CI 1.4 to 6.2) and for breast cancer in the presence of DCIS (OR=2.1 95% CI=1.2 to 3.6). The NOD2 3020insC allele is relatively common (in Poland 7.3% of individuals) and may be responsible for an important fraction of cancer cases. We estimate that the lifetime cancer risk among carriers of this allele is 30% higher than that of individuals with two wild-type alleles.
引用
收藏
页码：59 / 63
页数：5
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