Inhibition of B cell receptor-mediated B cell activation by coengagement of CD19 and FcγRIIb with Fc-engineered antibodies

被引：0
|
作者：
Szymkowski, David E. [1 ]
Chu, Seung Y. [1 ]
Vostiar, Igor [1 ]
Horton, Holly M. [1 ]
Karki, Sher [1 ]
Moore, Gregory L. [1 ]
Lazar, Greg A. [1 ]
Pong, Erik [1 ]
Joyce, Patrick F. [1 ]
Desjarlais, John [1 ]
机构：
[1] Xencor Inc, Monrovia, CA USA
来源：
ARTHRITIS AND RHEUMATISM | 2008年 / 58卷 / 09期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：S443 / S443
页数：1
相关论文
共 50 条
  • [41] Expression and modulation of the inhibitory Fcγ receptor, FcγRIIb (CD32b), on human dendritic cells (DCs)
    Boruchov, AM
    Young, JW
    BLOOD, 2003, 102 (11) : 522A - 522A
  • [42] Potent targeting of B cell lymphoma and plasma cell tumors by a tetravalent, Fc-engineered antibody directed against the glycoantigen CD75s.
    Klausz, Katja
    Karimzadeh-Tabrizi, Amir
    Buck, Malena
    Otte, Anna
    Krohn, Steffen
    Kellner, Christian
    Klapper, Wolfram
    Peipp, Matthias
    Gramatzki, Martin
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
  • [43] Ligation of human Fc receptor like-2 by monoclonal antibodies down-regulates B-cell receptor-mediated signalling
    Shabani, Mahdi
    Bayat, Ali Ahmad
    Jeddi-Tehrani, Mahmood
    Rabbani, Hodjatallah
    Hojjat-Farsangi, Mohammad
    Ulivieri, Cristina
    Amirghofran, Zahra
    Baldari, Cosima Tatiana
    Shokri, Fazel
    IMMUNOLOGY, 2014, 143 (03) : 341 - 353
  • [44] Degradation of radioiodinated B cell monoclonal antibodies: Inhibition via a Fc gamma-receptor-II-mediated mechanism and by drugs
    Vervoordeldonk, SF
    Balkenende, AY
    vandenBerg, H
    vondemBorne, AEGK
    vanderSchoot, CE
    VanLeeuwen, EF
    SlaperCortenbach, ICM
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 1996, 42 (01) : 24 - 30
  • [45] An Fc-engineered CD19 antibody engages NK cells and macrophages and is effective in Xenograft models of acute lymphoblastic leukemia
    Kellner, C.
    Alsadeq, A.
    Cario, G.
    Vieth, S.
    Rosskopf, S.
    Burmeister, Y.
    Klausz, K.
    Valerius, T.
    Schrappe, M.
    Gramatzki, M.
    Peipp, M.
    Schewe, D. M.
    ONCOLOGY RESEARCH AND TREATMENT, 2016, 39 : 202 - 202
  • [46] B lymphocyte memory:: Role of stromal cell complement and FcγRIIB receptors
    Barrington, RA
    Pozdnyakova, O
    Zafari, MR
    Benjamin, CD
    Carroll, MC
    JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (09): : 1189 - 1199
  • [47] SHIP1-mediated negative regulation of cell activation and proliferation by FcγRIIB
    Daëron, M
    Bruhns, P
    Lesourne, R
    Malbec, O
    Fridman, WH
    ACTIVATING AND INHIBITORY IMMUNOGLOBULIN-LIKE RECEPTORS, 2001, : 141 - 152
  • [48] Engineered IgG1-Fc Molecules Define Valency Control of Cell Surface Fcγ Receptor Inhibition and Activation in Endosomes
    Bailey, Elizabeth M.
    Choudhury, Amit
    Vuppula, Harika
    Ortiz, Daniel F.
    Schaeck, John
    Manning, Anthony M.
    Bosques, Carlos J.
    Hoppe, Adam D.
    FRONTIERS IN IMMUNOLOGY, 2021, 11
  • [49] SHIP recruitment attenuates FcγRIIB-induced B cell apoptosis
    Pearse, RN
    Kawabe, T
    Bolland, S
    Guinamard, R
    Kurosaki, T
    Ravetch, JV
    IMMUNITY, 1999, 10 (06) : 753 - 760
  • [50] Enhanced Phagocytic Eradication of Leukemia Cells by Combination of an FC-Engineered CD19 Antibody with CD47 Immune Checkpoint Blockade
    Roesner, T.
    Eichholz, K. M.
    Otte, A.
    Winterberg, D.
    Wichmann, C.
    Windisch, R.
    Humpe, A.
    Schewe, D. M.
    Gramatzki, M.
    Valerius, T.
    Peipp, M.
    Kellner, C.
    ANNALS OF HEMATOLOGY, 2019, 98 : S59 - S59
12345