Cytotoxic lignans from Viburnum foetidum

被引：13
|
作者：
Li, Hong [1 ]
Luo, Yuanguo [1 ]
Ma, Yan [1 ]
Zeng, Jun [1 ]
Zhang, Xu [1 ]
Wang, Dong [1 ]
Hu, Chunlin [1 ]
机构：
[1] 181 Hosp PLA, Dept Anesthesiol, Guilin 541002, Guangxi Provinc, Peoples R China
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2013年 / 36卷 / 10期
关键词：
Viburnum foetidum; Caprifliaceae; Lignans; Cytotoxicity; AWABUKI;
D O I：
10.1007/s12272-013-0218-z
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new lignans, 3,4,4'-trihydroxy-3',9-dimethoxy-9,9'-epoxylignan (1), 3,4'-dihydroxy-3',4, 9-trimethoxy-9,9'-epoxylignan (2), together with one known compound, 4,4'-dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan (3), were isolated from the 95 % EtOH extract of Viburnum foetidum. The structures of the two new compounds were elucidated on the basis of 1D, 2D-NMR, and mass spectral analysis. All the lignans were in vitro evaluated for their cytotoxic activities against four tumor cell lines (A549, SK-OV-3, SKMEL-2 and HCT15).
引用
收藏
页码：1211 / 1214
页数：4
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