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Cytotoxic lignans from Larrea tridentata

被引：26
|
作者：
Lambert, JD
Sang, SM
Dougherty, A
Caldwell, CG
Meyers, RO
Dorr, RT
Timmermann, BN
机构：
[1] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Piscataway, NJ 08854 USA
[2] Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA
[3] Univ Arizona, Ctr Canc, Tucson, AZ 85724 USA
来源：
PHYTOCHEMISTRY | 2005年 / 66卷 / 07期
关键词：
Larrea tridentata; Zygophyllaceae; lignans; flavanone; cytotoxicity; cancer; Creosote bush;
D O I：
10.1016/j.phytochem.2005.02.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Six lignans, including the cyclolignan 3,4'-dihydroxy-3',4'-dimethoxy-6,7'-cyclolignan, were isolated from the flowering tops of Larrea tridentata. Additionally the flavanone, (S)-4', 5-dihydroxy-7-methoxyflavanone, was isolated for the first time from L. tridentata or any member of the family Zygophyllaceae. All of the compounds were assessed for their growth inhibitory activity against human breast cancer, human colon cancer and human melanoma cell lines. The lignans had IC50 values of 5-60 mu M with the linear butane-type lignans being the most potent, and it was found that colon cancer cells were the least sensitive cell type tested. The relative potency of linear butane type lignans against human breast cancer appears to correlate positively with the number of O-methyl groups present on the molecule. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：811 / 815
页数：5
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