Synthesis of Unnatural α-Amino Acid Derivatives via Photoredox Activation of Inert C(sp3)-H Bonds

被引：28

作者：

Babawale, Florence ^{[1
]}

Murugesan, Kathiravan ^{[1
]}

Narobe, Rok ^{[1
]}

Koenig, Burkhard ^{[1
]}

机构：

[1] Univ Regensburg, Fac Chem & Pharm, Inst Organ Chem, D-93053 Regensburg, Germany

来源：

ORGANIC LETTERS | 2022年

关键词：

HYDROGEN-ATOM TRANSFER; C-H; DECATUNGSTATE ANION; STEREOSELECTIVE-SYNTHESIS; TRANSFER HAT; FUNCTIONALIZATION; PHOTOCATALYSIS; RADICALS; BENZOPHENONE; ALKYLATION;

D O I：

10.1021/acs.orglett.2c01822

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of unnatural, tertiary amino acids is a challenging task. While decarboxylation-radical addition has been an important strategy for their formation, the use of alkyl radicals from C(sp(3))-H bonds has not been fully explored. Herein, we report a photocatalytic protocol for the synthesis of unnatural alpha-amino esters employing abundant alkanes and imines retaining full atom economy. When this method is applied, several amino acid derivatives are synthesized in moderate to good yields.

引用

页码：4793 / 4797

页数：5

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