Stereoselective substitution of α-aminoalkylferrocenes with diorganozincs.: A fast synthesis of new chiral FERRIPHOS ligands for asymmetric catalysis

被引：44
|
作者：
Lotz, M
Ireland, T
Perea, JJA
Knochel, P
机构：
[1] Univ Munich, Inst Organ Chem, D-81377 Munich, Germany
[2] Degussa Huls AG, Fine Chem Div, D-63403 Hanau, Germany
来源：
TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 10期
关键词：
D O I：
10.1016/S0957-4166(99)00182-2
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A direct stereoselective substitution of alpha-aminoalkylferrocenes of type 3 with organozinc reagents provides chiral ferrocenes which can be converted to the FERRIPHOS ligands of type 1 in a one-pot procedure. These FERRIPHOS ligands have been used for the Rh-catalyzed asymmetric hydrogenation of an enol acetate with 94.9% ee. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1839 / 1842
页数：4
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