Eph/ephrin signalling during development

被引：166
|
作者：
Klein, Ruediger [1 ]
机构：
[1] Max Planck Inst Neurobiol, Dept Mol Neurobiol, D-82152 Munich, Germany
来源：
DEVELOPMENT | 2012年 / 139卷 / 22期
关键词：
Cell migration; Eph; Ephrin-mediated vascular development; Axon guidance; Topographic mapping; MOTOR AXON GUIDANCE; SYNAPSE FORMATION; EPH; ENDOCYTOSIS; REPULSION; CLEAVAGE; DISEASE; LIMB; PHOSPHORYLATION; SYNAPTOGENESIS;
D O I：
10.1242/dev.074997
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Eph receptors and their membrane-tethered ligands have important functions in development. Trans interactions of Eph receptors with ephrins at cell-cell interfaces promote a variety of cellular responses, including repulsion, attraction and migration. Eph-ephrin signalling can be bi-directional and controls actin cytoskeleton dynamics, thereby leading to changes in cellular shape. This article provides an overview of the general structures and signalling mechanisms, and of typical developmental functions along with cell biological principles.
引用
收藏
页码：4105 / 4109
页数：5
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