MicroRNAs in Liver Regeneration

被引：42

作者：

Chen, Xiaoyu ^{[1
]}

Zhao, Yingying ^{[1
]}

Wang, Eel ^{[1
]}

Bei, Yihua ^{[2
,3
]}

Xiao, Junjie ^{[2
,3
]}

Yang, Changqing ^{[1
]}

机构：

[1] Tongji Univ, Sch Med, Tongji Hosp, Div Gastroenterol & Hepatol,Digest Dis Inst, Shanghai 200065, Peoples R China

[2] Shanghai Univ, Sch Life Sci, Expt Ctr Life Sci, Regenerat & Ageing Lab, Shanghai 200444, Peoples R China

[3] Shanghai Univ, Sch Life Sci, Shanghai Key Lab Bioenergy Crops, Shanghai 200444, Peoples R China

来源：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2015年 / 37卷 / 02期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

MicroRNAs; Liver regeneration; Hepatocyte proliferation; CELL-CYCLE PROGRESSION; HEPATOCELLULAR-CARCINOMA CELLS; ENDOTHELIAL GROWTH-FACTOR; PARTIAL-HEPATECTOMY; GENE-EXPRESSION; HEPATOCYTE PROLIFERATION; DOWN-REGULATION; CANCER-CELLS; RAT-LIVER; MESENCHYMAL TRANSITION;

D O I：

10.1159/000430381

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Liver maintains a unique tremendous regeneration capacity in response to partial hepatectomy (PH) or injury. Hepatocyte proliferation critically contributes to the process of liver regeneration (LR), which is regulated by various cytokines and growth factors. However, the molecular basis of LR remains unclear. Emerging evidence indicates that microRNAs (miRNAs, miRs) are involved in controlling hepatocyte proliferation during LR. In this review, an overview is provided to cover recent achievements in studies on the roles of miRNAs in LR. Studies on the regulatory effects of miRNAs and associated molecular mechanisms in LR will help enhance the understanding of the regenerative process and open up a new prospect for liver transplantation. Copyright (C) 2015 S. Karger AG, Basel

引用

页码：615 / 628

页数：14

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