ONE-POT SYNTHESIS OF 1H-BENZIMIDAZOLE DERIVATIVES USING THIAMINE HYDROCHLORIDE AS A REUSABLE ORGANOCATALYST

被引：38
|
作者：
Lei, Min
Ma, Lei [1 ,2 ]
Hu, Lihong [1 ,2 ]
机构：
[1] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2012年 / 42卷 / 20期
基金：
中国国家自然科学基金;
关键词：
Aldehyde; 1H-benzimidazole; green chemistry; o-phenylenediamine; thiamine hydrochloride (VB1); BENZIMIDAZOLE DERIVATIVES; EFFICIENT SYNTHESIS; 2-SUBSTITUTED BENZIMIDAZOLES; CATALYST; 2-ARYL-1-ARYLMETHYL-1H-BENZIMIDAZOLES; ALDEHYDES; CONDENSATION; DESIGN; SYSTEM; WATER;
D O I：
10.1080/00397911.2011.573610
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient one-pot synthesis of 1H-benzimidazole derivatives using thiamine hydrochloride (VB1) as the organocatalyst from o-phenylenediamine and aldehyde in dimethylformamide is described. Compared to classical reaction conditions, this new method consistently has the advantages of excellent yields, metal-ion-free procedure, and good recovery and reusablity of catalyst.
引用
收藏
页码：2981 / 2993
页数：13
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