Direct Sulfanylation of 4-Quinazolinone via C-OH Bond Activation: An Efficient Route to 2-Aryl-4-sulfanylquinazolines

被引：20
|
作者：
Peng, Yiyuan [1 ,2 ]
Qiu, Guanyinsheng [3 ,4 ]
Yang, Qin [1 ,2 ]
Yuan, Jianjun [1 ,2 ]
Deng, Zhihong [3 ,4 ]
机构：
[1] Jiangxi Normal Univ, Key Lab Small Fuct Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China
[2] Jiangxi Normal Univ, Coll Life Sci, Nanchang 330022, Jiangxi, Peoples R China
[3] Jiangxi Normal Univ, Key Lab Green Chem, Nanchang 330022, Jiangxi, Peoples R China
[4] Jiangxi Normal Univ, Coll Chem, Nanchang 330022, Jiangxi, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2012年 / 44卷 / 08期
基金：
中国国家自然科学基金;
关键词：
nitrogen heterocycles; multicomponent reactions; sulfinylations; thiols; bond activation; GROWTH-FACTOR RECEPTOR; TYROSINE KINASE INHIBITORS; SOLID-PHASE SYNTHESIS; ARYL BORONIC ACIDS; ACRIDONE ALKALOIDS; DIHYDROFOLATE-REDUCTASE; ANTIFUNGAL ACTIVITY; ANTICANCER AGENT; SITE INHIBITORS; SNAR REACTIONS;
D O I：
10.1055/s-0031-1289731
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The direct sulfanylation of 2-aryl-4-quinazolinones with thiols via C-OH bond activation under mild conditions is described. The method affords the corresponding 2-aryl-4-sulfanylquinazolines in good to excellent yield.
引用
收藏
页码：1237 / 1246
页数：10
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