Neurotrophic tyrosine receptor kinase (NTRK) inhibitors represent the latest advancement as a treatment option in targeted therapies for malignant disease. NTRK gene fusions involving NTRK1, 2 or 3 are implicated as genetics drivers for a number of tumour types which arise within adult and paedatric patients. NTRK inhibitors (Larotrectinib and Entrectinib) are effective agents which have demonstrated clinical benefit in the treatment of NTRK fusion positive solid tumours. Larotrectinib represents the first targeted agent to receive approval from international authorisation and commissioning bodies for the treatment of a specific genetic expression indiscriminate of the site from which the tumour has arisen. As such NTRK inhibitors could pave the way for international healthcare bodies to adopt a similar approach for future targeted therapies thereby altering the manner in which healthcare providers and patients are able to access and utilise innovative, targeted treatment options in future. The potential implications of this new approach are likely to impact upon several aspects of the traditional authorisation and commissioning pathways with potential changes to the design of clinical trials, the review and approval process by regulatory bodies and immunohistopathology services.
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Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Div Hematol, Dept Internal Med, Istanbul, TurkiyeIstanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Div Hematol, Dept Internal Med, Istanbul, Turkiye
Ozmen, Deniz
Alpaydin, Duygu Demet
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Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Istanbul, TurkiyeIstanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Div Hematol, Dept Internal Med, Istanbul, Turkiye
Alpaydin, Duygu Demet
Saldogan, Muhammed Ali
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Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Istanbul, TurkiyeIstanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Div Hematol, Dept Internal Med, Istanbul, Turkiye
Saldogan, Muhammed Ali
Eskazan, Ahmet Emre
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Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Div Hematol, Dept Internal Med, Istanbul, Turkiye
Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Dept Internal Med, Div Hematol, TR-34303 Istanbul, TurkiyeIstanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Div Hematol, Dept Internal Med, Istanbul, Turkiye
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Univ Calif Los Angeles, David Geffen Sch Med, Div Dermatol, Dept Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Div Dermatol, Dept Med, Los Angeles, CA 90095 USA
Yang, Jason J.
Maloney, Nolan J.
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Stanford Univ, Sch Med, Dept Dermatol, Palo Alto, CA 94304 USAUniv Calif Los Angeles, David Geffen Sch Med, Div Dermatol, Dept Med, Los Angeles, CA 90095 USA
Maloney, Nolan J.
Nguyen, Kevin A.
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Univ Calif Los Angeles, David Geffen Sch Med, Div Dermatol, Dept Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Div Dermatol, Dept Med, Los Angeles, CA 90095 USA
Nguyen, Kevin A.
Worswick, Scott
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Univ Southern Calif, Keck Sch Med, Dept Dermatol, Los Angeles, CA 90007 USAUniv Calif Los Angeles, David Geffen Sch Med, Div Dermatol, Dept Med, Los Angeles, CA 90095 USA
Worswick, Scott
Smogorzewski, Jan
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Harbor UCLA Med Ctr, Div Dermatol, Torrance, CA 90509 USAUniv Calif Los Angeles, David Geffen Sch Med, Div Dermatol, Dept Med, Los Angeles, CA 90095 USA
Smogorzewski, Jan
Bach, Daniel Q.
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Univ Calif Los Angeles, David Geffen Sch Med, Div Dermatol, Dept Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Div Dermatol, Dept Med, Los Angeles, CA 90095 USA