Chaperoning RNA Polymerase II through repressive chromatin

被引：2

作者：

Faralli, Herve ^{[1
]}

Dilworth, F. Jeffrey ^{[1
,2
]}

机构：

[1] Ottawa Hosp Res Inst, Regenerat Med Program, Sprott Ctr Stem Cell Res, Ottawa, ON, Canada

[2] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON, Canada

来源：

EMBO JOURNAL | 2013年 / 32卷 / 08期

基金：

加拿大健康研究院;

关键词：

GENE-EXPRESSION; ELONGATION;

D O I：

10.1038/emboj.2013.64

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The histone chaperone Spt6 is known to facilitate transcriptional elongation while preventing spurious initiation of transcription within the coding region of genes. A recent publication in The EMBO Journal (Wang et al, 2013) identifies an additional mechanism by which Spt6 promotes gene expression by demonstrating that it tethers the histone demethylase UTX/KDM6A to the elongating RNA Polymerase II, thereby enabling the removal of repressive H3K27me3 marks within developmentally important muscle genes.

引用

页码：1067 / 1068

页数：2

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